Detalles de la búsqueda
1.
Repositioning Dequalinium as Potent Muscarinic Allosteric Ligand by Combining Virtual Screening Campaigns and Experimental Binding Assays.
Int J Mol Sci
; 21(17)2020 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-32825082
2.
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone.
Xenobiotica
; 48(5): 478-487, 2018 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-28608746
3.
Muscarine-like compounds derived from a pyrolysis product of cellulose.
Org Biomol Chem
; 13(22): 6291-8, 2015 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25968655
4.
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.
Bioorg Med Chem Lett
; 24(15): 3255-9, 2014 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24980056
5.
1,2,4-Benzothiadiazine-1,1-dioxide derivatives as ionotropic glutamate receptor ligands: synthesis and structure-activity relationships.
Arch Pharm (Weinheim)
; 347(11): 777-85, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25204434
6.
Playing with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and P-glycoprotein inhibitors.
Molecules
; 19(10): 16543-72, 2014 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25317581
7.
Design, synthesis and binding affinity of acetylcholine carbamoyl analogues.
Bioorg Med Chem Lett
; 23(23): 6481-5, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24128660
8.
Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101.
J Med Chem
; 65(20): 13946-13966, 2022 10 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-36201615
9.
Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents.
Eur J Med Chem
; 200: 112405, 2020 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32492595
10.
Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus.
J Med Chem
; 63(11): 5763-5782, 2020 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32374602
11.
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors.
Eur J Pharmacol
; 883: 173183, 2020 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32534072
12.
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.
Bioorg Med Chem
; 17(24): 8174-85, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19896386
13.
Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity.
Arch Pharm (Weinheim)
; 342(10): 605-13, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19753564
14.
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide.
Bioorg Med Chem Lett
; 18(2): 614-8, 2008 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18077164
15.
Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.
Bioorg Med Chem
; 16(10): 5490-500, 2008 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18455407
16.
Safety aspects of iodinated contrast media related to their physicochemical properties: a pharmacoepidemiology study in two Tuscany hospitals.
Eur J Clin Pharmacol
; 64(7): 723-37, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18401577
17.
3-Iodothyroacetic acid (TA1), a by-product of thyroid hormone metabolism, reduces the hypnotic effect of ethanol without interacting at GABA-A receptors.
Neurochem Int
; 115: 31-36, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29032008
18.
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor.
J Med Chem
; 61(8): 3712-3725, 2018 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29589445
19.
Discovery of ß-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
J Med Chem
; 61(12): 5380-5394, 2018 06 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-29851481
20.
Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.
Br J Pharmacol
; 175(13): 2635-2652, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29579779