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1.
GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile.
Antimicrob Agents Chemother
; 66(1): e0187621, 2022 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34780263
2.
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Bioorg Med Chem
; 67: 116833, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35605346
3.
Design, synthesis and SAR study of novel C2-pyrazolopyrimidine amides and amide isosteres as allosteric integrase inhibitors.
Bioorg Med Chem Lett
; 30(21): 127516, 2020 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32860982
4.
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 30(22): 127531, 2020 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32890685
5.
Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action.
Proteins
; 83(2): 331-50, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25401969
6.
Genotypic correlates of susceptibility to HIV-1 attachment inhibitor BMS-626529, the active agent of the prodrug BMS-663068.
J Antimicrob Chemother
; 69(3): 573-81, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24128669
7.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc Natl Acad Sci U S A
; 108(37): 15366-71, 2011 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-21896751
8.
In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068.
Antimicrob Agents Chemother
; 56(7): 3498-507, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22547625
9.
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.
J Med Chem
; 65(6): 4949-4971, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35235334
10.
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
ACS Med Chem Lett
; 13(6): 972-980, 2022 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35707159
11.
Inhibition of envelope-mediated CD4+-T-cell depletion by human immunodeficiency virus attachment inhibitors.
Antimicrob Agents Chemother
; 53(11): 4726-32, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19721067
12.
5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.
J Med Chem
; 62(3): 1348-1361, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30609350
13.
Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination.
J Pharm Sci
; 105(3): 1036-42, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26886323
14.
Increased sensitivity of HIV variants selected by attachment inhibitors to broadly neutralizing antibodies.
Virology
; 402(2): 256-61, 2010 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-20400170
15.
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects.
J Med Chem
; 52(23): 7778-87, 2009 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19769332
16.
Envelope conformational changes induced by human immunodeficiency virus type 1 attachment inhibitors prevent CD4 binding and downstream entry events.
J Virol
; 80(8): 4017-25, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16571818
17.
Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions.
J Virol
; 77(19): 10528-36, 2003 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-12970437
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