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1.
Spongipyran Synthetic Studies. Total Synthesis of (+)-Spongistatin 2.
Tetrahedron
; 65(33): 6470-6488, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20161196
2.
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 18(1): 215-9, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17988864
3.
Recent advances in the discovery of melanin-concentrating hormone receptor antagonists.
Curr Opin Drug Discov Devel
; 9(4): 496-508, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16889232
4.
Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
J Med Chem
; 49(7): 2294-310, 2006 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16570926
5.
Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors.
Eur J Med Chem
; 124: 36-48, 2016 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-27560281
6.
Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.
J Med Chem
; 48(7): 2274-7, 2005 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15801820
7.
Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.
J Med Chem
; 48(15): 4746-9, 2005 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-16033253
8.
The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.
Angew Chem Int Ed Engl
; 40(1): 196-199, 2001 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-11169711
9.
The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2.
Angew Chem Int Ed Engl
; 40(1): 196-199, 2001 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29711943
10.
The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, NIH Postdoctoral Fellowships to A.M.B. and W.H.M., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr. George T. Furst, Dr. Patrick J. Carroll, Dr. Rakesh Kohli, and Mr John Dykins of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra.
Angew Chem Int Ed Engl
; 40(1): 191-195, 2001 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-11169710
11.
The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment.
Angew Chem Int Ed Engl
; 40(1): 191-195, 2001 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29711948
12.
Melanin concentrating hormone receptor antagonists as antiobesity agents: from M2 to MCHR-1.
Curr Top Med Chem
; 7(15): 1440-54, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17897031
13.
Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 17(22): 6290-4, 2007 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17890085
14.
Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists.
Bioorg Med Chem
; 14(10): 3285-99, 2006 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16442800
15.
Bicyclo[3.1.0]hexyl urea melanin concentrating hormone (MCH) receptor-1 antagonists: impacting hERG liability via aryl modifications.
Bioorg Med Chem Lett
; 16(16): 4262-5, 2006 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16753297
16.
Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.
Bioorg Med Chem Lett
; 15(23): 5234-6, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16202583
17.
Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity.
Expert Opin Investig Drugs
; 13(9): 1113-22, 2004 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-15330743
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