Detalles de la búsqueda
1.
Evidence for investigating GSK-3 inhibitors as potential therapeutics for severe COVID-19.
Biochem Biophys Res Commun
; 605: 171-176, 2022 05 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35367865
2.
A novel GSK-3 inhibitor binds to GSK-3ß via a reversible, time and Cys-199-dependent mechanism.
Bioorg Med Chem
; 40: 116179, 2021 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33991821
3.
Toll-Like Receptors Signaling in the Tumor Microenvironment.
Adv Exp Med Biol
; 1223: 81-97, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32030686
4.
Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3.
Am J Physiol Cell Physiol
; 317(6): C1289-C1303, 2019 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31553649
5.
Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions.
Inflamm Res
; 63(4): 277-85, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24346141
6.
Inhibition of LPS-induced TLR4 signaling products in murine macrophages by phenylmethimazole: an assay methodology for screening potential phenylmethimazole analogs.
Drug Dev Res
; 75(8): 497-509, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25408546
7.
Mechanistic insights into SARS-CoV-2 spike protein induction of the chemokine CXCL10.
Sci Rep
; 14(1): 11179, 2024 05 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38750069
8.
Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice.
Molecules
; 18(4): 3841-58, 2013 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-23535518
9.
Anti-Inflammatory and Therapeutic Effects of a Novel Small-Molecule Inhibitor of Inflammation in a Male C57BL/6J Mouse Model of Obesity-Induced NAFLD/MAFLD.
J Inflamm Res
; 16: 5339-5366, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38026235
10.
Phenylmethimazole inhibits production of proinflammatory mediators and is protective in an experimental model of endotoxic shock*.
Crit Care Med
; 40(3): 886-94, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22020240
11.
Phenylmethimazole blocks dsRNA-induced IRF3 nuclear translocation and homodimerization.
Molecules
; 17(10): 12365-77, 2012 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23090018
12.
Toll-Like Receptor 3 Is Critical to the Pancreatic Islet Milieu That Is Required for Coxsackievirus B4-Induced Type 1 Diabetes in Female Nonobese Diabetic Mice.
Pancreas
; 51(1): 48-55, 2022 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35195595
13.
Consequences of Both Coxsackievirus B4 and Type 1 Diabetes on Female Non-Obese Diabetic Mouse Kidneys.
Microorganisms
; 9(11)2021 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34835482
14.
Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.
Eur J Pharmacol
; 883: 173340, 2020 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32634441
15.
Evidence that knock down of GSK-3ß in Chronic Myelogenous Leukemia cells augments IFN-γ-induced apoptosis.
Leuk Res
; 99: 106464, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33130330
16.
Coxsackievirus B4 Exposure Results in Variable Pattern Recognition Response in the Kidneys of Female Non-Obese Diabetic Mice Before Establishment of Diabetes.
Viral Immunol
; 33(7): 494-506, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32352894
17.
Phenylmethimazole abrogates diet-induced inflammation, glucose intolerance and NAFLD.
J Endocrinol
; 237(3): 337-351, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29666152
18.
High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration.
Endocrinology
; 148(9): 4226-37, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17525119
19.
Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms.
J Endocrinol
; 193(1): 93-106, 2007 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-17400807
20.
TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.
Oncotarget
; 8(69): 113295-113302, 2017 Dec 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29371911