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1.
Pharmacological Characterization of a Potent Inhibitor of Autotaxin in Animal Models of Inflammatory Bowel Disease and Multiple Sclerosis.
J Pharmacol Exp Ther
; 359(1): 207-14, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27516465
2.
Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.
Drug Metab Dispos
; 41(4): 714-26, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23305709
3.
Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model.
Invest New Drugs
; 30(3): 936-49, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21360050
4.
Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent.
J Med Chem
; 51(7): 2302-6, 2008 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18314943
5.
Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.
ACS Med Chem Lett
; 7(9): 857-61, 2016 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27660691
6.
A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation.
Endocrinology
; 146(10): 4524-35, 2005 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16002528
7.
A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.
J Med Chem
; 48(22): 6772-5, 2005 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-16250633
8.
Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy.
J Med Chem
; 48(7): 2270-3, 2005 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15801819
9.
Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents.
J Med Chem
; 47(22): 5367-80, 2004 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15481975
10.
A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models.
Mol Cancer Ther
; 10(11): 2200-10, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21900693
11.
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases.
Cancer Res
; 71(5): 1849-57, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21233335
12.
Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.
Bioorg Med Chem Lett
; 17(13): 3544-9, 2007 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17482463
13.
Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles by liver microsomes: interspecies differences and structure-metabolism relationships.
Drug Metab Dispos
; 30(10): 1070-6, 2002 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-12228182
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