Detalles de la búsqueda
1.
Cyclopropanecarboxylic acid esters as potential prodrugs with enhanced hydrolytic stability.
Org Lett
; 10(3): 509-11, 2008 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-18181639
2.
Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
J Med Chem
; 60(23): 9807-9820, 2017 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29088532
3.
Totally Endoscopic Robotic Mitral Valve Surgery.
AORN J
; 104(4): 293-306, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-27692076
4.
A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models.
Diabetes
; 51(4): 1083-7, 2002 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-11916929
5.
Preorganization of the hydroxyethylene dipeptide isostere: the preferred conformation in solution resembles the conformation bound to BACE.
J Med Chem
; 48(24): 7623-7, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16302802
6.
Rational design, synthesis, and structure-activity relationships of aryltriazoles as novel corticotropin-releasing factor-1 receptor antagonists.
J Med Chem
; 48(5): 1540-9, 2005 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-15743196
7.
Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core.
J Med Chem
; 48(12): 4100-10, 2005 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15943483
8.
Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists.
J Med Chem
; 48(16): 5104-7, 2005 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-16078829
9.
Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists.
J Med Chem
; 47(19): 4787-98, 2004 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-15341493
10.
Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.
J Med Chem
; 47(10): 2422-5, 2004 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-15115385
11.
Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors.
Brain Res
; 952(2): 200-10, 2002 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-12376180
12.
Coupling of 2-Substituted 1-Fluorovinylstannanes with Organic Halides Catalyzed by Palladium(0)/Copper(I) Iodide. A Mild and Stereospecific Method to Monofluoroolefins.
J Org Chem
; 64(10): 3476-3482, 1999 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-11674468
13.
Mitsunobu approach to the synthesis of optically active alpha,alpha-disubstituted amino acids.
Org Lett
; 11(4): 807-10, 2009 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-19159255
14.
Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine.
J Med Chem
; 52(22): 6958-61, 2009 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-19860433
15.
Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex.
Bioorg Med Chem Lett
; 16(1): 191-5, 2006 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16249081
16.
Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.
Bioorg Med Chem Lett
; 14(15): 3943-7, 2004 Aug 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15225703
17.
Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists.
Bioorg Med Chem Lett
; 13(19): 3367-70, 2003 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-12951127
18.
Synthesis of 1-methyl-3-phenylpyrazolo[4,3-b]pyridines via a methylation of 4-phthalimino-3-phenylpyrazoles and optimization toward highly potent corticotropin-releasing factor type-1 antagonists.
Bioorg Med Chem Lett
; 13(19): 3371-4, 2003 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-12951128
19.
Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARalpha/gamma agonists.
J Org Chem
; 68(7): 2623-32, 2003 Apr 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-12662031
20.
Synthesis of benzoylpyrimidines as antagonists of the corticotropin-releasing factor-1 receptor.
Bioorg Med Chem Lett
; 14(15): 3869-73, 2004 Aug 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15225687