Búsqueda | Biblioteca Virtual en Salud

1.

Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.

Hanisak, Jennifer; Seganish, W Michael; McElroy, William T; Tang, Haiquin; Zhang, Rui; Tsui, Hon-Chung; Fischmann, Theirry; Tulshian, Deen; Tata, James; Sondey, Christopher; Devito, Kristine; Fossetta, James; Garlisi, Charles G; Lundell, Daniel; Niu, Xiaoda.

Bioorg Med Chem Lett ; 26(17): 4250-5, 2016 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-27476420

2.

Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4.

McElroy, William T; Michael Seganish, W; Jason Herr, R; Harding, James; Yang, Jinhai; Yet, Larry; Komanduri, Venukrishnan; Prakash, Koraboina Chandra; Lavey, Brian; Tulshian, Deen; Greenlee, William J; Sondey, Christopher; Fischmann, Thierry O; Niu, Xiaoda.

Bioorg Med Chem Lett ; 25(9): 1836-41, 2015 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-25870132

3.

Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4.

Seganish, W Michael; McElroy, William T; Herr, R Jason; Brumfield, Stephanie; Greenlee, William J; Harding, James; Komanduri, Venukrishnan; Matasi, Julius; Prakash, Koraboina Chandra; Tulshian, Deen; Yang, Jinhai; Yet, Larry; Devito, Kristine; Fossetta, James; Garlisi, Charles G; Lundell, Daniel; Niu, Xiaoda; Sondey, Christopher.

Bioorg Med Chem Lett ; 25(16): 3203-7, 2015 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-26115573

4.

Studies toward welwitindolinones: formal syntheses of N-methylwelwitindolinone C isothiocyanate and related natural products.

Fu, Tsung-Hao; McElroy, William T; Shamszad, Mariam; Heidebrecht, Richard W; Gulledge, Brian; Martin, Stephen F.

Tetrahedron ; 69(27-28): 5588-5603, 2013 Jul 08.

Artículo en Inglés | MEDLINE | ID: mdl-23976796

5.

Pyrazoloquinolines as PDE10A inhibitors: discovery of a tool compound.

McElroy, William T; Tan, Zheng; Basu, Kallol; Yang, Shu-Wei; Smotryski, Jennifer; Ho, Ginny D; Tulshian, Deen; Greenlee, William J; Mullins, Deborra; Guzzi, Mario; Zhang, Xiaoping; Bleickardt, Carina; Hodgson, Robert.

Bioorg Med Chem Lett ; 22(3): 1335-9, 2012 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-22227212

6.

Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.

Yang, Shu-Wei; Smotryski, Jennifer; McElroy, William T; Tan, Zheng; Ho, Ginny; Tulshian, Deen; Greenlee, William J; Guzzi, Mario; Zhang, Xiaoping; Mullins, Deborra; Xiao, Li; Hruza, Alan; Chan, Tze-Ming; Rindgen, Diane; Bleickardt, Carina; Hodgson, Robert.

Bioorg Med Chem Lett ; 22(1): 235-9, 2012 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-22142545

7.

The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.

Ho, Ginny D; Yang, Shu-Wei; Smotryski, Jennifer; Bercovici, Ana; Nechuta, Terry; Smith, Elizabeth M; McElroy, William; Tan, Zheng; Tulshian, Deen; McKittrick, Brian; Greenlee, William J; Hruza, Alan; Xiao, Li; Rindgen, Diane; Mullins, Deborra; Guzzi, Mario; Zhang, Xiaoping; Bleickardt, Carina; Hodgson, Robert.

Bioorg Med Chem Lett ; 22(2): 1019-22, 2012 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-22222034

8.

High-Throughput Screening to Identify Small Molecules That Selectively Inhibit APOL1 Protein Level in Podocytes.

Choy, Jonathan; Kan, Yanqing; Cifelli, Steve; Johnson, Josephine; Chen, Michelle; Shiao, Lin-Lin; Zhou, Haihong; Previs, Stephen; Lei, Ying; Johnstone, Richard; Liaw, Andy; Saigal, Ashmita; Hu, Lufei; Ramos, Robert; Visconti, Richard; McElroy, William T; Kreamer, Anthony; Wildey, Mary-Jo; Peier, Andrea; Shin, Myung K; Imbriglio, Jason; Ren, Zhao; Hoek, Maarten; Weinglass, Adam; Ai, Xi.

SLAS Discov ; 26(9): 1225-1237, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-34218698

9.

Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors: an updated patent review (2016-2018).

McElroy, William T.

Expert Opin Ther Pat ; 29(4): 243-259, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30916602

10.

Live Cell Membranome cDNA Screen: A Novel Homogenous Live Cell Binding Assay to Study Membrane Protein-Ligand Interaction.

Shen, Xun; Smith, Elizabeth; Ai, Xi; McElroy, William T; Liaw, Andy; Kreamer, Tony; Chang, Meiping; Devito, Kristine; Hudak, Edward; Xu, Serena; Pei, Yi; Sur, Sylvie; Peier, Andrea; Li, Jing.

SLAS Discov ; 24(10): 978-986, 2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31491347

11.

Application of palladium-catalyzed allylic arylation to the synthesis of a (+/-)-7-deoxypancratistatin analogue.

Shukla, Krupa H; Boehmler, Debra J; Bogacyzk, Suzanne; Duvall, Bridget R; Peterson, William A; McElroy, William T; Deshong, Philip.

Org Lett ; 8(19): 4183-6, 2006 Sep 14.

Artículo en Inglés | MEDLINE | ID: mdl-16956182

12.

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.

Seganish, W Michael; Fischmann, Thierry O; Sherborne, Brad; Matasi, Julius; Lavey, Brian; McElroy, William T; Tulshian, Deen; Tata, James; Sondey, Christopher; Garlisi, Charles G; Devito, Kristine; Fossetta, James; Lundell, Daniel; Niu, Xiaoda.

ACS Med Chem Lett ; 6(8): 942-7, 2015 Aug 13.

Artículo en Inglés | MEDLINE | ID: mdl-26288698

13.

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation.

McElroy, William T; Tan, Zheng; Ho, Ginny; Paliwal, Sunil; Li, Guoqing; Seganish, W Michael; Tulshian, Deen; Tata, James; Fischmann, Thierry O; Sondey, Christopher; Bian, Hong; Bober, Loretta; Jackson, James; Garlisi, Charles G; Devito, Kristine; Fossetta, James; Lundell, Daniel; Niu, Xiaoda.

ACS Med Chem Lett ; 6(6): 677-82, 2015 Jun 11.

Artículo en Inglés | MEDLINE | ID: mdl-26101573

14.

Siloxane-based cross-coupling of bromopyridine derivatives: studies for the synthesis of streptonigrin and lavendamycin.

McElroy, William T; DeShong, Philip.

Org Lett ; 5(25): 4779-82, 2003 Dec 11.

Artículo en Inglés | MEDLINE | ID: mdl-14653672

15.

Potential mechanisms responsible for chlorotriazine-induced alterations in catecholamines in pheochromocytoma (PC12) cells.

Das, Parikshit C; McElroy, William K; Cooper, Ralph L.

Life Sci ; 73(24): 3123-38, 2003 Oct 31.

Artículo en Inglés | MEDLINE | ID: mdl-14550852

16.

Formal syntheses of naturally occurring welwitindolinones.

Fu, Tsung-hao; McElroy, William T; Shamszad, Mariam; Martin, Stephen F.

Org Lett ; 14(15): 3834-7, 2012 Aug 03.

Artículo en Inglés | MEDLINE | ID: mdl-22830424

17.

Fisiologia e bioquímica da célula

McElroy, William David.

São Paulo; Edgard Blucher; 1972. 144 p. ilus, tab, graf.

Monografía en Portugués | SES-SP, SESSP-IALACERVO | ID: biblio-1072481

Biblioteca Virtual en Salud

Hipertensión

Su selección (0)

Formato de exportación:

Exportar: