Detalles de la búsqueda
1.
The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues.
Biochim Biophys Acta
; 1203(1): 93-8, 1993 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-8105896
2.
A molecular model for cinnamyl alcohol dehydrogenase, a plant aromatic alcohol dehydrogenase involved in lignification.
Biochim Biophys Acta
; 1202(1): 61-9, 1993 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-8373826
3.
Evidence for gene duplication forming similar binding folds for NAD(P)H and FAD in pyridine nucleotide-dependent flavoenzymes.
FEBS Lett
; 279(1): 5-8, 1991 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-1995341
4.
Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.
J Med Chem
; 41(9): 1367-70, 1998 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-9554869
5.
Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
J Med Chem
; 41(2): 148-56, 1998 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-9457238
6.
A direct link between LY83583, a selective repressor of cyclic GMP formation, and glutathione metabolism.
Biochem Pharmacol
; 45(12): 2547-9, 1993 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-8101080
7.
Homology modelling of the dihydrofolate reductase-thymidylate synthase bifunctional enzyme of Leishmania major, a potential target for rational drug design in leishmaniasis.
Drug Des Discov
; 11(4): 269-88, 1994 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-7727680
8.
A homology-derived structural model of the murine macrophage inflammatory protein, MIP-1 alpha.
Drug Des Discov
; 11(1): 47-59, 1994 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-8068819
9.
Synthesis of symmetric disulfides as potential alternative substrates for trypanothione reductase and glutathione reductase: Part 1.
Amino Acids
; 9(4): 327-42, 1995 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24178881
10.
Synthesis of asymmetric disulfides as potential alternative substrates for trypanothione reductase and glutathione reductase: Part 2.
Amino Acids
; 9(4): 343-51, 1995 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24178882
11.
Molecular design of DNA-directed ligands with specific interactions: solution NMR studies of the interaction of a m-hydroxy analogue of Hoechst 33258 with d(CGCGAATTCGCG)2.
Biochemistry
; 33(28): 8442-52, 1994 Jul 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-7518248
12.
Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine.
J Enzyme Inhib
; 12(3): 161-73, 1997 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-9314113
13.
Inhibitors of glutathione reductase as potential antimalarial drugs. Kinetic cooperativity and effect of dimethyl sulphoxide on inhibition kinetics.
J Enzyme Inhib
; 13(5): 327-45, 1998 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-9793837
14.
Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead.
Amino Acids
; 22(4): 297-308, 2002 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12107758
15.
Predictability of designing specific binding interactions for DNA minor groove ligands from NMR spectroscopy and molecular modeling: a copper(II)-activated DNA cleaver based on Hoechst 33258.
Biochemistry
; 34(50): 16240-4, 1995 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-8845347
16.
Rational design of peptide-based inhibitors of trypanothione reductase as potential antitrypanosomal drugs.
Amino Acids
; 6(3): 295-9, 1994 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24189737
17.
Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures.
Biochem J
; 286 ( Pt 1): 9-11, 1992 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-1355650
18.
Synthesis and enzymology of modified N-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide++ + disulphides as alternative substrates for trypanothione reductase from Trypanosoma cruzi: Part 3.
Amino Acids
; 17(2): 175-83, 1999.
Artículo
en Inglés
| MEDLINE | ID: mdl-10524275
19.
Use of transferred nuclear-Overhauser-effect spectroscopy to measure the bound conformation of a disulphide-replaced analogue of glutathione disulphide as an inhibitor of yeast glutathione reductase.
Eur J Biochem
; 221(2): 793-9, 1994 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-8174559
20.
A homology model of the three-dimensional structure of human O6-alkylguanine-DNA alkyltransferase based on the crystal structure of the C-terminal domain of the Ada protein from Escherichia coli.
Anticancer Drug Des
; 10(1): 75-95, 1995 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-7695814