Detalles de la búsqueda
1.
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R).
J Enzyme Inhib Med Chem
; 38(1): 2241674, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37548154
2.
Apoptotic and anti-angiogenic effects of propolis against human bladder cancer: molecular docking and in vitro screening.
Biomarkers
; 27(2): 138-150, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-34927500
3.
Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors.
J Enzyme Inhib Med Chem
; 37(1): 1884-1902, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35801486
4.
Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies.
J Enzyme Inhib Med Chem
; 37(1): 1389-1403, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35577416
5.
Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies.
J Enzyme Inhib Med Chem
; 37(1): 2206-2222, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35980113
6.
Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies.
J Enzyme Inhib Med Chem
; 37(1): 2489-2511, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36093880
7.
Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors.
J Enzyme Inhib Med Chem
; 37(1): 573-591, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35012403
8.
New quinoxalin-2(1H)-one-derived VEGFR-2 inhibitors: Design, synthesis, in vitro anticancer evaluations, in silico ADMET, and docking studies.
Arch Pharm (Weinheim)
; 355(7): e2200048, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35437829
9.
Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management.
Molecules
; 27(11)2022 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35684529
10.
Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2.
Molecules
; 27(13)2022 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35807326
11.
Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation.
Molecules
; 27(15)2022 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35956997
12.
Discovery of Some Heterocyclic Molecules as Bone Morphogenetic Protein 2 (BMP-2)-Inducible Kinase Inhibitors: Virtual Screening, ADME Properties, and Molecular Docking Simulations.
Molecules
; 27(17)2022 Aug 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-36080338
13.
Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies.
Molecules
; 27(19)2022 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36234734
14.
Antitrypanosomal, Antitopoisomerase-I, and Cytotoxic Biological Evaluation of Some African Plants Belonging to Crassulaceae; Chemical Profiling of Extract Using UHPLC/QTOF-MS/MS.
Molecules
; 27(24)2022 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36557948
15.
Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors.
Bioorg Med Chem
; 29: 115872, 2021 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33214036
16.
Design, synthesis and molecular modeling of new quinazolin-4(3H)-one based VEGFR-2 kinase inhibitors for potential anticancer evaluation.
Bioorg Chem
; 109: 104695, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33647743
17.
Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR.
Bioorg Chem
; 110: 104794, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33735711
18.
Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma.
Bioorg Chem
; 107: 104532, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33334586
19.
Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation.
Bioorg Chem
; 114: 105105, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34175720
20.
Discovery of thieno[2,3-d]pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents.
Bioorg Chem
; 112: 104947, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33964580