Detalles de la búsqueda
1.
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors.
Bioorg Chem
; 131: 106331, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36587505
2.
Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives.
Biochemistry
; 61(17): 1705-1722, 2022 09 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35972884
3.
Defined stereoisomers of 2â³-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase.
Bioorg Med Chem
; 68: 116875, 2022 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35716588
4.
Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors.
Molecules
; 27(8)2022 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35458724
5.
Synthesis, biological evaluation, and molecular docking studies of deoxygenated C-glycosides as LpxC inhibitors.
Bioorg Chem
; 117: 105403, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34758434
6.
Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)-based fluorescence quencher.
Bioorg Chem
; 117: 105425, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34695733
7.
Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors.
Bioorg Med Chem
; 28(13): 115529, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32386952
8.
Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies.
Bioorg Med Chem
; 27(10): 1997-2018, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30954331
9.
Synthesis and biochemical evaluation of two novel N-hydroxyalkylated cyclosporin A analogs.
Org Biomol Chem
; 16(23): 4338-4349, 2018 06 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-29845172
10.
Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition.
Molecules
; 23(2)2018 Feb 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29393896
11.
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.
Molecules
; 23(3)2018 Mar 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29498707
12.
Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.
Arch Pharm (Weinheim)
; 350(8)2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28639720
13.
Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors.
Bioorg Med Chem
; 24(5): 1032-44, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26827141
14.
Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.
J Chem Inf Model
; 54(10): 3005-19, 2014 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-25243797
15.
Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors.
Bioorg Med Chem
; 22(3): 1016-28, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24412340
16.
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2.
J Med Chem
; 2024 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38847803
17.
Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds.
Pharmaceuticals (Basel)
; 16(7)2023 Jul 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37513880
18.
Current trends in development of HDAC-based chemotherapeutics.
Life Sci
; 308: 120946, 2022 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36096240
19.
Strategies To Design Selective Histone Deacetylase Inhibitors.
ChemMedChem
; 16(9): 1336-1359, 2021 05 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33428327
20.
Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.
ChemMedChem
; 15(7): 571-584, 2020 04 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31816172