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1.
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.
Bioorg Med Chem Lett
; 22(22): 6832-8, 2012 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23046961
2.
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
J Med Chem
; 61(23): 10415-10439, 2018 12 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30130103
3.
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
J Med Chem
; 60(7): 3094-3108, 2017 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28257199
4.
In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels.
PLoS One
; 12(9): e0185079, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28945765
5.
Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.
ACS Chem Biol
; 10(4): 1094-8, 2015 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-25571984
6.
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.
Mol Biosyst
; 11(10): 2709-12, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25959423
7.
Potent inhibitors of LpxC for the treatment of Gram-negative infections.
J Med Chem
; 55(2): 914-23, 2012 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22175825
8.
Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.
J Med Chem
; 55(4): 1662-70, 2012 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-22257165
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