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1.
Blocking potential metabolic sites on NAT to improve its safety profile while retaining the pharmacological profile.
Bioorg Chem
; 148: 107489, 2024 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-38797065
2.
Exploring naltrexamine derivatives featuring azaindole moiety via nitrogen-walk approach to investigate their in vitro pharmacological profiles at the mu opioid receptor.
Bioorg Med Chem Lett
; 41: 127953, 2021 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33766769
3.
Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14ß-dihydroxy-6ß-[(4'-pyridyl) carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors.
Bioorg Chem
; 109: 104702, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33631465
4.
Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments.
J Med Chem
; 67(11): 9552-9574, 2024 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38814086
5.
Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression.
J Med Chem
; 67(1): 603-619, 2024 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38156970
6.
Activation of the insulin-like growth factor-1 receptor alters p27 regulation by the epidermal growth factor receptor in oral squamous carcinoma cells.
J Oral Pathol Med
; 42(4): 332-8, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23106397
7.
Structural Alterations of the "Address" Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity.
J Med Chem
; 66(1): 577-595, 2023 01 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36538027
8.
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment.
J Med Chem
; 65(6): 4991-5003, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35255683
9.
Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure-Activity Relationship Study on Nalfurafine Analogues.
ACS Chem Neurosci
; 13(24): 3608-3628, 2022 12 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36449691
10.
Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists.
J Med Chem
; 65(6): 5095-5112, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35255685
11.
Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators.
Future Med Chem
; 13(6): 551-573, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33590767
12.
PRAS40 Phosphorylation Correlates with Insulin-Like Growth Factor-1 Receptor-Induced Resistance to Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells.
Mol Cancer Res
; 18(9): 1392-1401, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32467173
13.
Antitumor effect of insulin-like growth factor-1 receptor inhibition in head and neck squamous cell carcinoma.
Laryngoscope
; 130(6): 1470-1478, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31433065
14.
Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells.
Front Oncol
; 9: 13, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30729097
15.
Effect of Adipose-Derived Stem Cells on Head and Neck Squamous Cell Carcinoma.
Otolaryngol Head Neck Surg
; 158(5): 882-888, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29313435
16.
Synergistic apoptosis in head and neck squamous cell carcinoma cells by co-inhibition of insulin-like growth factor-1 receptor signaling and compensatory signaling pathways.
Head Neck
; 37(12): 1722-32, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24986420
17.
Nanoimmunoassay to Detect Responses in Head and Neck Cancer: Feasibility in a Mouse Model.
Otolaryngol Head Neck Surg
; 151(1): 92-9, 2014 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-24687941
18.
p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks.
Cell Signal
; 26(8): 1627-35, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24662264
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