Detalles de la búsqueda
1.
Design, synthesis and structure-activity relationship of N-phenyl aromatic amide derivatives as novel xanthine oxidase inhibitors.
Bioorg Chem
; 133: 106403, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36801790
2.
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors.
Bioorg Med Chem Lett
; 60: 128582, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35077850
3.
Synthesis and identification of a novel skeleton of N-(pyridin-3-yl) proline as a selective CDK4/6 inhibitor with anti-breast cancer activities.
Bioorg Chem
; 119: 105547, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34906858
4.
Design, synthesis and biological evaluation of N-(4-alkoxy-3-(1H-tetrazol-1-yl)phenyl) heterocyclic aromatic amide derivatives as xanthine oxidase inhibitors.
Bioorg Chem
; 127: 105938, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35752100
5.
Discovery of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer growth and angiogenesis.
Bioorg Chem
; 119: 105469, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34915285
6.
A possible covalent xanthine oxidase inhibitor TS10: Inhibition mechanism, metabolites identification and PDPK assessment.
Bioorg Chem
; 128: 106064, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35987190
7.
N-(3-cyano-1H-indol-5-yl)isonicotinamide and N-(3-cyano-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamide derivatives: Novel amide-based xanthine oxidase inhibitors.
Bioorg Chem
; 115: 105181, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34329991
8.
Novel 4,5-dihydrospiro[benzo[c]azepine-1,1'-cyclohexan]-3(2H)-one derivatives as PARP-1 inhibitors: Design, synthesis and biological evaluation.
Bioorg Chem
; 111: 104840, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33780687
9.
Amide-based xanthine oxidase inhibitors bearing an N-(1-alkyl-3-cyano-1H-indol-5-yl) moiety: Design, synthesis and structure-activity relationship investigation.
Bioorg Chem
; 117: 105417, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34673452
10.
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs.
Bioorg Chem
; 94: 103385, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31669094
11.
Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors.
Bioorg Chem
; 96: 103575, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31962202
12.
Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM).
Bioorg Chem
; 103: 104189, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32890996
13.
Synthesis and biological evaluation of novel (E)-N'-benzylidene hydrazides as novel c-Met inhibitors through fragment based virtual screening.
J Enzyme Inhib Med Chem
; 35(1): 468-477, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31902266
14.
Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model.
J Enzyme Inhib Med Chem
; 35(1): 235-244, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31760818
15.
Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations.
Molecules
; 25(18)2020 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32911607
16.
Comparative pharmacokinetics study of leonurine and stachydrine in normal rats and rats with cold-stagnation and blood-stasis primary dysmenorrhoea after the administration of Leonurus japonicus houtt electuary.
J Sep Sci
; 42(9): 1725-1732, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-30839168
17.
Fragment-Based Structural Optimization of a Natural Product Itampolin A as a p38α Inhibitor for Lung Cancer.
Mar Drugs
; 17(1)2019 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30642059
18.
Identification of Novel PI3Kδ Selective Inhibitors by SVM-Based Multistage Virtual Screening and Molecular Dynamics Simulations.
Int J Mol Sci
; 20(23)2019 Nov 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-31795217
19.
Development and Validation of a Sensitive UHPLC-MS/MS Method for the Measurement of Gardneramine in Rat Plasma and Tissues and its Application to Pharmacokinetics and Tissue Distribution Study.
Molecules
; 24(21)2019 Oct 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-31683708
20.
Design, synthesis and anticancer activities evaluation of novel 5H-dibenzo[b,e]azepine-6,11-dione derivatives containing 1,3,4-oxadiazole units.
Bioorg Med Chem Lett
; 28(5): 847-852, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29456106