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1.
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
J Neurosci
; 29(45): 14271-86, 2009 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-19906975
2.
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.
Mol Pharmacol
; 78(6): 1105-23, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-20923853
3.
Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).
Bioorg Med Chem Lett
; 20(17): 5175-8, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20667732
4.
3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.
Bioorg Med Chem Lett
; 20(15): 4390-4, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20598884
5.
(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction.
ACS Chem Neurosci
; 2(8): 471-482, 2011 Aug 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-21927650
6.
Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans.
J Infect Dis
; 199(6): 872-80, 2009 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19239339
7.
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).
J Med Chem
; 52(14): 4115-8, 2009 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-19469556
8.
Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptorâ 5 (mGlu5): from an artificial neural network virtual screen to an in vivo tool compound.
ChemMedChem
; 7(3): 406-14, 2012 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-22267125
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