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1.
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Immunity
; 56(9): 2121-2136.e6, 2023 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37659412
2.
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Nature
; 586(7827): 113-119, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32707573
3.
Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Nature
; 2024 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38890463
4.
pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography.
Biophys J
; 123(5): 622-637, 2024 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38327055
5.
Development of a sensitive microplate assay for characterizing RNA methyltransferase activity: Implications for epitranscriptomics and drug development.
J Biol Chem
; 299(10): 105257, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37716702
6.
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads.
Bioorg Med Chem Lett
; 96: 129489, 2023 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37770002
7.
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.
J Infect Dis
; 224(Supplement_1): S1-S21, 2021 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34111271
8.
Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.
J Virol
; 94(11)2020 05 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-32188728
9.
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors.
Molecules
; 26(19)2021 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34641337
10.
Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors.
Biochemistry
; 58(44): 4424-4435, 2019 11 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31549827
11.
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Bioorg Med Chem Lett
; 28(15): 2605-2610, 2018 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29970308
12.
Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus.
J Mol Recognit
; 30(11)2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28608547
13.
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.
Bioorg Med Chem Lett
; 27(11): 2432-2438, 2017 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28427814
14.
X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.
J Biol Chem
; 290(42): 25293-306, 2015 Oct 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-26296883
15.
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.
J Biol Chem
; 290(32): 19403-22, 2015 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26055715
16.
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
J Virol
; 89(9): 4907-17, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25694594
17.
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.
PLoS Pathog
; 10(5): e1004113, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24854014
18.
Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme.
Arch Biochem Biophys
; 612: 35-45, 2016 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27756680
19.
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.
J Virol
; 88(21): 12511-27, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25142582
20.
Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance.
J Virol
; 88(20): 11886-98, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25100843