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1.
Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction.
Drug Metab Dispos
; 49(7): 540-547, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33863817
2.
Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse.
Xenobiotica
; 49(5): 602-610, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-29768081
3.
Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions.
Mol Pharm
; 14(5): 1754-1759, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28345929
4.
Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model.
Drug Metab Dispos
; 44(11): 1736-1741, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27538915
5.
Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor.
Drug Metab Dispos
; 43(6): 864-9, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25813936
6.
Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.
Drug Metab Dispos
; 42(6): 1067-73, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24671957
7.
Investigations into the mechanisms of pyridine ring cleavage in vismodegib.
Drug Metab Dispos
; 42(3): 343-51, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24389420
8.
Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib.
Mol Pharm
; 11(11): 4199-207, 2014 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25243894
9.
Assessment of the hepatic CYP reductase null mouse model and its potential application in drug discovery.
Mol Pharm
; 11(3): 1062-8, 2014 Mar 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-24450768
10.
Solvent-based formulations for intravenous mouse pharmacokinetic studies: tolerability and recommended solvent dose limits.
Xenobiotica
; 44(3): 235-41, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24138296
11.
Balancing Blood Sample Volume with 3Rs: Implementation and Best Practices for Small Molecule Toxicokinetic Assessments in Rats.
ILAR J
; 57(2): 157-165, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28053069
12.
Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.
Drug Metab Lett
; 10(2): 91-100, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27063863
13.
Prediction of drug distribution in subcutaneous xenografts of human tumor cell lines and healthy tissues in mouse: application of the tissue composition-based model to antineoplastic drugs.
J Pharm Sci
; 104(4): 1508-21, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25615572
14.
Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS.
Bioanalysis
; 6(11): 1445-57, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25046046
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