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1.
An improved protocol for amino acid type-selective isotope labeling in insect cells.
J Biomol NMR
; 68(4): 237-247, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28711957
2.
Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target.
Anal Biochem
; 497: 8-17, 2016 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26743718
3.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc Natl Acad Sci U S A
; 108(37): 15366-71, 2011 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-21896751
4.
Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex.
Bioorg Med Chem Lett
; 23(14): 4107-11, 2013 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23747226
5.
Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 7): 768-74, 2011 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21795790
6.
Assessing compound binding to the Eg5 motor domain using a thermal shift assay.
Anal Biochem
; 392(1): 59-69, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19497292
7.
Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation.
Protein Sci
; 17(2): 240-50, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18227430
8.
NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.
J Med Chem
; 49(16): 5013-7, 2006 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-16884313
9.
Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening.
J Med Chem
; 58(6): 2799-808, 2015 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25764119
10.
Acyl guanidine inhibitors of ß-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
J Med Chem
; 55(21): 9208-23, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-23030502
11.
Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects.
J Med Chem
; 51(19): 6225-9, 2008 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-18771253
12.
Protein-ligand NOE matching: a high-throughput method for binding pose evaluation that does not require protein NMR resonance assignments.
J Am Chem Soc
; 128(22): 7252-63, 2006 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16734479
13.
Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118).
Arch Biochem Biophys
; 445(1): 9-18, 2006 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16364232
14.
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).
Bioorg Med Chem Lett
; 15(4): 1101-6, 2005 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15686921
15.
An inhibitor binding pocket distinct from the catalytic active site on human beta-APP cleaving enzyme.
Biochemistry
; 44(34): 11567-73, 2005 Aug 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-16114893
16.
Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism.
J Biol Chem
; 278(7): 4582-9, 2003 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-12458195
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