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1.
Dihydropyrimidine dehydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: FUSAFE individual patient data meta-analysis.
Br J Cancer
; 130(5): 808-818, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38225422
2.
Systematic review of time to subsequent therapy as a candidate surrogate endpoint in advanced solid tumors.
Future Oncol
; 19(23): 1627-1639, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37589145
3.
Real-world outcomes in patients with advanced endometrial cancer: A retrospective cohort study of US electronic health records.
Gynecol Oncol
; 164(2): 325-332, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34952707
4.
Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity.
Br J Clin Pharmacol
; 87(8): 3234-3243, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33491253
5.
Evaluating the role of ENOSF1 and TYMS variants as predictors in fluoropyrimidine-related toxicities: An IPD meta-analysis.
Pharmacol Res
; 152: 104594, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31838077
6.
Effectiveness and safety of reduced-dose fluoropyrimidine therapy in patients carrying the DPYD*2A variant: A matched pair analysis.
Int J Cancer
; 144(9): 2347-2354, 2019 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30485432
7.
DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis.
Lancet Oncol
; 19(11): 1459-1467, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30348537
8.
Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers.
Br J Clin Pharmacol
; 84(12): 2761-2769, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30047584
9.
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Br J Cancer
; 116(11): 1415-1424, 2017 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28427087
10.
Letter regarding Zhao et al. entitled " DPYD gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia".
Tumour Biol
; 39(6): 1010428317701629, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28618970
11.
Increased risk of severe fluoropyrimidine-associated toxicity in patients carrying a G to C substitution in the first 28-bp tandem repeat of the thymidylate synthase 2R allele.
Int J Cancer
; 138(1): 245-53, 2016 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26189437
12.
Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity.
Int J Cancer
; 138(11): 2752-61, 2016 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26804235
13.
Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study.
Cancer
; 122(9): 1434-43, 2016 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26970343
14.
Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study.
Invest New Drugs
; 34(1): 119-28, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26643663
15.
Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers.
Br J Clin Pharmacol
; 82(3): 706-16, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27161955
16.
Clinical outcome in patients treated with simultaneous integrated boost - intensity modulated radiation therapy (SIB-IMRT) with and without concurrent chemotherapy for squamous cell carcinoma of the anal canal.
Acta Oncol
; 55(6): 760-6, 2016 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-26878244
17.
Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data.
Lancet Oncol
; 16(16): 1639-50, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26603945
18.
Baclofen overdose treated with continuous venovenous hemofiltration.
Eur J Clin Pharmacol
; 71(3): 357-61, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25567218
19.
A Nomogram to Predict Severe Toxicity in DPYD Wild-Type Patients Treated With Capecitabine-Based Anticancer Regimens.
Clin Pharmacol Ther
; 115(2): 269-277, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37957132
20.
Safety, tolerability, pharmacokinetics, and antitumor activity of adavosertib in Japanese patients with advanced solid tumors: A phase I, open-label study.
Cancer Treat Res Commun
; 39: 100809, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38593512