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1.
Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
Proc Natl Acad Sci U S A
; 116(7): 2545-2550, 2019 02 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30683716
2.
Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces.
J Biol Chem
; 293(44): 17166-17187, 2018 11 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30217822
3.
Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled.
J Biol Chem
; 290(51): 30596-606, 2015 Dec 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26504084
4.
Near-planar solution structures of mannose-binding lectin oligomers provide insight on activation of lectin pathway of complement.
J Biol Chem
; 287(6): 3930-45, 2012 Feb 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-22167201
5.
Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations.
J Biol Chem
; 285(2): 1053-65, 2010 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-19850925
6.
Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody.
Sci Rep
; 11(1): 1712, 2021 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33462327
7.
Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins.
Sci Rep
; 11(1): 10475, 2021 05 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34006961
8.
Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds.
J Immunol Methods
; 494: 113051, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33794223
9.
A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2.
Sci Adv
; 7(15)2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33837087
10.
An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells.
Leuk Res
; 108: 106626, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34062328
11.
A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency.
Antiviral Res
; 194: 105147, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34375715
12.
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection.
Sci Rep
; 11(1): 10617, 2021 05 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-34012108
13.
Multiple interactions of complement Factor H with its ligands in solution: a progress report.
Adv Exp Med Biol
; 703: 25-47, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20711705
14.
Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats.
MAbs
; 12(1): 1752529, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32316838
15.
A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS.
Nat Commun
; 11(1): 3233, 2020 06 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32591521
16.
Immunopolymer Lipid Nanoparticles for Delivery of Macromolecules to Antigen-Expressing Cells.
ACS Appl Bio Mater
; 3(12): 8481-8495, 2020 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35019618
17.
Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model.
Sci Rep
; 9(1): 5760, 2019 04 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30962539
18.
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun
; 10(1): 2607, 2019 06 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31197133
19.
BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
Elife
; 72018 07 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29989546
20.
Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor.
Acta Crystallogr F Struct Biol Commun
; 74(Pt 3): 143-149, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29497017