Detalles de la búsqueda
1.
Distinct mechanism for antidepressant activity by blockade of central substance P receptors.
Science
; 281(5383): 1640-5, 1998 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-9733503
2.
The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets.
Neuropharmacology
; 39(4): 652-63, 2000 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-10728886
3.
Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist.
J Med Chem
; 41(23): 4607-14, 1998 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-9804700
4.
Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs.
J Med Chem
; 43(6): 1234-41, 2000 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-10737756
5.
Characterization of the binding and activity of a high affinity, pseudoirreversible morpholino tachykinin NK1 receptor antagonist.
Eur J Pharmacol
; 325(2-3): 253-61, 1997 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-9163573
6.
In vitro and in vivo predictors of the anti-emetic activity of tachykinin NK1 receptor antagonists.
Eur J Pharmacol
; 326(2-3): 201-9, 1997 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-9196273
7.
2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.
J Med Chem
; 39(9): 1760-2, 1996 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-8627597
8.
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements.
Bioorg Med Chem Lett
; 11(11): 1437-40, 2001 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-11378372
9.
Characterization of the interaction of diacylpiperazine antagonists with the human neurokinin-1 receptor: identification of a common binding site for structurally dissimilar antagonists.
Mol Pharmacol
; 47(4): 660-5, 1995 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-7536886
10.
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes.
Bioorg Med Chem Lett
; 11(18): 2469-73, 2001 Sep 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-11549449
11.
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes.
Bioorg Med Chem Lett
; 11(2): 259-64, 2001 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-11206473
12.
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes.
Bioorg Med Chem Lett
; 11(2): 265-70, 2001 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-11206474
13.
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes.
Bioorg Med Chem Lett
; 11(18): 2475-9, 2001 Sep 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-11549450
14.
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity.
Bioorg Med Chem Lett
; 11(20): 2741-5, 2001 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-11591514
15.
Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection.
Bioorg Med Chem Lett
; 11(24): 3103-6, 2001 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-11720852
16.
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
Bioorg Med Chem Lett
; 11(24): 3099-102, 2001 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-11720851
17.
The discovery of sulfonylated dipeptides as potent VLA-4 antagonists.
Bioorg Med Chem Lett
; 11(20): 2709-13, 2001 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-11591507
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