Detalles de la búsqueda
1.
Computational discovery, structural optimization and biological evaluation of novel inhibitors targeting transient receptor potential vanilloid type 3 (TRPV3).
Bioorg Chem
; 114: 105093, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34182309
2.
Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors.
Bioorg Med Chem Lett
; 30(9): 127061, 2020 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32173197
3.
Computational discovery and biological evaluation of novel inhibitors targeting histone-lysine N-methyltransferase SET7.
Bioorg Med Chem
; 28(7): 115372, 2020 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32088124
4.
Serum-plasma matched metabolomics for comprehensive characterization of benign thyroid nodule and papillary thyroid carcinoma.
Int J Cancer
; 144(4): 868-876, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30318614
5.
Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment.
Eur J Med Chem
; 264: 116025, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38086189
6.
Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation.
J Med Chem
; 67(9): 7283-7300, 2024 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38676656
7.
Design, Synthesis, and Antitumor Activity Evaluation of Novel VISTA Small Molecule Inhibitors.
J Med Chem
; 67(5): 3590-3605, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38412237
8.
Fibroblast expression of transmembrane protein smoothened governs microenvironment characteristics after acute kidney injury.
J Clin Invest
; 2024 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38713523
9.
Targeting polyketide synthase 13 for the treatment of tuberculosis.
Eur J Med Chem
; 259: 115702, 2023 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37544185
10.
Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer.
J Med Chem
; 66(6): 4215-4230, 2023 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36800260
11.
Limonin, a natural ERK2 agonist, protects against ischemic acute kidney injury.
Int J Biol Sci
; 19(9): 2860-2878, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37324945
12.
Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance.
J Med Chem
; 66(21): 14633-14652, 2023 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37885208
13.
Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment.
J Med Chem
; 66(3): 2064-2083, 2023 02 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36579489
14.
Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell.
Acta Pharm Sin B
; 12(6): 2808-2831, 2022 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-35755294
15.
Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma.
Eur J Med Chem
; 228: 114024, 2022 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34875521
16.
Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.
Nat Commun
; 13(1): 2903, 2022 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35614066
17.
Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia.
J Med Chem
; 65(1): 857-875, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34958208
18.
Discovery, Optimization, and Evaluation of Selective CDK4/6 Inhibitors for the Treatment of Breast Cancer.
J Med Chem
; 65(22): 15102-15122, 2022 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36350721
19.
Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.
J Med Chem
; 65(14): 9873-9892, 2022 07 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35834807
20.
Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents.
Acta Pharm Sin B
; 12(12): 4446-4457, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36561991