Detalles de la búsqueda
1.
LC-HRMS-based targeted metabolomics for high-throughput and quantitative analysis of 21 growth inhibition-related metabolites in Chinese hamster ovary cell fed-batch cultures.
Biomed Chromatogr
; 36(5): e5348, 2022 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-35083760
2.
Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product-related impurities in CHO cells.
Biotechnol Bioeng
; 117(7): 1946-1960, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32246763
3.
Phosphorylation of NLRC4 is critical for inflammasome activation.
Nature
; 490(7421): 539-42, 2012 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-22885697
4.
FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality.
Biotechnol Bioeng
; 114(3): 632-644, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27666939
5.
Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells.
Biotechnol Bioeng
; 113(10): 2100-6, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26989081
6.
PILRα negatively regulates mouse inflammatory arthritis.
J Immunol
; 193(2): 860-70, 2014 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24935926
7.
Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.
Proc Natl Acad Sci U S A
; 110(39): 15770-5, 2013 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-24019479
8.
Strategies to improve CHO cell culture performance: Targeted deletion of amino acid catabolism and apoptosis genes paired with growth inhibitor supplementation.
Biotechnol Prog
; : e3471, 2024 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38629737
9.
SPEED-MODE cell line development (CLD): Reducing Chinese hamster ovary (CHO) CLD timelines via earlier suspension adaptation and maximizing time spent in the exponential growth phase.
Biotechnol Prog
; : e3479, 2024 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38716635
10.
Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation.
J Immunol
; 186(11): 6553-61, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21508259
11.
Combining regulated and constitutive protein expression significantly boosts protein expression by increasing productivity without affecting CHO cell growth.
Biotechnol Prog
; 39(3): e3337, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36878664
12.
Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling.
Biotechnol Prog
; 39(5): e3354, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37161726
13.
Increased targeting of donor switch region and IgE in Sgamma1-deficient B cells.
J Immunol
; 185(1): 166-73, 2010 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20511552
14.
Bax and Bak knockout apoptosis-resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed-batch culture process.
Biotechnol Prog
; 38(2): e3228, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34951158
15.
Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study.
Biotechnol Prog
; 38(6): e3290, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36537257
16.
An arrayed CRISPR screen reveals Myc depletion to increase productivity of difficult-to-express complex antibodies in CHO cells.
Synth Biol (Oxf)
; 7(1): ysac026, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36452067
17.
A ribonucleoprotein-based decaplex CRISPR/Cas9 knockout strategy for CHO host engineering.
Biotechnol Prog
; 38(1): e3212, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34538022
18.
DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination.
Adv Immunol
; 101: 163-89, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19231595
19.
Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle.
Biotechnol Prog
; 37(5): e3193, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34288605
20.
Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost-effective method for expression of complex molecules.
Biotechnol J
; 16(4): e2000230, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-33259700