Detalles de la búsqueda
1.
Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase.
Eur J Nucl Med Mol Imaging
; 49(4): 1148-1156, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34651220
2.
Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.
Epilepsia
; 63(6): 1580-1590, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35316533
3.
Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice.
Epilepsia
; 62(11): 2845-2857, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34510432
4.
Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse.
Xenobiotica
; 51(1): 51-60, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-32779988
5.
Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver.
Xenobiotica
; 49(12): 1379-1387, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30744481
6.
Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N-Methyl-d-Aspartate Receptor Antagonist-Induced Rat Models of Schizophrenia.
J Pharmacol Exp Ther
; 365(1): 179-188, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29440309
7.
Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver.
Xenobiotica
; 47(12): 1052-1063, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27892765
8.
Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders.
Chem Pharm Bull (Tokyo)
; 65(11): 1058-1077, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29093293
9.
[THE FREQUENCIES AND MANAGEMENT OF ADVERSE REACTIONS IN MULTI-DRUG RESISTANT TUBERCULOSIS TREATMENT].
Kekkaku
; 92(1): 11-19, 2017 Jan.
Artículo
en Japonés
| MEDLINE | ID: mdl-30646468
10.
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.
Bioorg Med Chem Lett
; 26(17): 4296-300, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27476141
11.
Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.
Bioorg Med Chem
; 23(15): 4777-4791, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26094943
12.
Phase I study of carboplatin combined with pemetrexed for elderly patients with advanced non-squamous non-small cell lung cancer.
Jpn J Clin Oncol
; 44(5): 472-8, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24688087
13.
Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice.
Drug Metab Dispos
; 41(4): 727-34, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23298863
14.
[Survey of the preoperative smoking cessation in patients for elective surgery in a university hospital].
Masui
; 62(8): 1013-6, 2013 Aug.
Artículo
en Japonés
| MEDLINE | ID: mdl-23984588
15.
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Bioorg Med Chem
; 20(18): 5507-17, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22898254
16.
Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.
Bioorg Med Chem
; 20(18): 5496-506, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22910224
17.
Lamotrigine and retigabine increase motor threshold in transcranial magnetic stimulation at the dose required to produce an antiepileptic effect against maximal electroshock-induced seizure in rats.
Neurosci Lett
; 771: 136460, 2022 02 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35051437
18.
Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
J Med Chem
; 65(4): 3343-3358, 2022 02 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35166541
19.
Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H).
Eur J Med Chem
; 240: 114612, 2022 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35863274
20.
Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.
Bioorg Med Chem
; 19(18): 5539-52, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21856163