Detalles de la búsqueda
1.
LAPTM4α is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins.
Biochem Biophys Res Commun
; 556: 9-15, 2021 06 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33836347
2.
Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences.
Biol Pharm Bull
; 44(11): 1635-1644, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34719641
3.
Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes.
Xenobiotica
; 51(11): 1247-1254, 2021 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-34727004
4.
Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Biochem Biophys Res Commun
; 525(2): 348-353, 2020 04 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32093886
5.
Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants.
Mol Pharmacol
; 95(5): 551-562, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30944207
6.
Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.
J Pharmacol Exp Ther
; 361(2): 199-208, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28228532
7.
Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region.
Mol Pharmacol
; 88(4): 800-12, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26243732
8.
Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.
Drug Metab Dispos
; 42(2): 229-38, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24255116
9.
Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products.
J Toxicol Sci
; 48(5): 263-272, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37121741
10.
Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols.
Biol Pharm Bull
; 35(10): 1811-7, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22878261
11.
[Protein-Protein Interactions as Underlying Regulatory Mechanisms of Drug-metabolizing Enzyme Function].
Yakugaku Zasshi
; 142(11): 1169-1175, 2022.
Artículo
en Japonés
| MEDLINE | ID: mdl-36328446
12.
Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells.
J Toxicol Sci
; 47(9): 381-387, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36047112
13.
Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4.
Front Pharmacol
; 13: 832931, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35295333
14.
Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products.
J Toxicol Sci
; 46(11): 509-514, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34719553
15.
DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis.
Sci Rep
; 11(1): 18532, 2021 09 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34535743
16.
The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway.
J Toxicol Sci
; 45(7): 401-409, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32612008
17.
Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells.
Biosci Rep
; 40(4)2020 04 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32266931
18.
The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9.
Drug Metab Pharmacokinet
; 35(5): 466-474, 2020 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-32883578
19.
UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression.
Br J Pharmacol
; 177(5): 1077-1089, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31660580
20.
Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal.
Cell Signal
; 40: 200-209, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28911860