Detalles de la búsqueda
1.
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.
J Pharmacol Exp Ther
; 363(3): 377-393, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28954811
2.
Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF1) receptor antagonists.
Bioorg Med Chem Lett
; 26(9): 2184-7, 2016 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27020524
3.
Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.
J Pharmacol Exp Ther
; 354(3): 340-9, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26109678
4.
Conformationally restricted homotryptamines. Part 6: indole-5-cycloalkyl methylamines as selective serotonin reuptake inhibitors.
Bioorg Med Chem Lett
; 23(10): 2948-50, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23578689
5.
Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists.
Bioorg Med Chem Lett
; 22(15): 4986-9, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22749422
6.
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents.
Bioorg Med Chem Lett
; 22(21): 6651-5, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23010264
7.
Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.
Bioorg Med Chem Lett
; 20(3): 1027-30, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20034793
8.
5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists.
Bioorg Med Chem Lett
; 20(12): 3579-83, 2010 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20483614
9.
Synthesis and structure-activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.
Bioorg Med Chem Lett
; 20(6): 1890-4, 2010 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20176478
10.
Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors.
Bioorg Med Chem Lett
; 19(15): 4031-3, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19560923
11.
Ex vivo assessment of binding site occupancy of monoamine reuptake inhibitors: methodology and biological significance.
Neuropharmacology
; 55(1): 63-70, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18538356
12.
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.
ACS Med Chem Lett
; 9(5): 472-477, 2018 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29795762
13.
Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling.
J Med Chem
; 50(9): 2269-72, 2007 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-17402721
14.
Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies.
Psychopharmacology (Berl)
; 190(3): 373-82, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17242925
15.
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
Eur J Pharmacol
; 799: 16-25, 2017 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28132910
16.
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents.
Eur J Pharmacol
; 807: 1-11, 2017 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28438647
17.
BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.
ACS Med Chem Lett
; 8(3): 366-371, 2017 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28337332
18.
Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators.
ACS Med Chem Lett
; 7(12): 1082-1086, 2016 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27994742
19.
Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy.
Neuropharmacology
; 102: 121-35, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26522433
20.
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia.
PLoS One
; 11(7): e0159996, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27467081