Detalles de la búsqueda
1.
Design and synthesis of novel spirocyclic carboxylic acids as potent and orally bioavailable DGAT1 inhibitors and their biological evaluation.
Bioorg Med Chem Lett
; 62: 128632, 2022 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35189320
2.
Recombinant irisin induces weight loss in high fat DIO mice through increase in energy consumption and thermogenesis.
Biochem Biophys Res Commun
; 519(2): 422-429, 2019 11 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31522816
3.
Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.
Bioorg Med Chem Lett
; 29(2): 238-243, 2019 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30503633
4.
Discovery and pharmacological evaluation of indole derivatives as potent and selective RORγt inverse agonist for multiple autoimmune conditions.
Bioorg Med Chem Lett
; 29(16): 2208-2217, 2019 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31272795
5.
Evaluation of separate role of intestine and liver in first pass metabolism of budesonide in rat.
Xenobiotica
; 48(12): 1206-1214, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29165024
6.
Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis.
Bioorg Med Chem Lett
; 27(8): 1867-1873, 2017 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28279528
7.
Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2's-hydroxy-3's-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors.
Bioorg Med Chem
; 25(20): 5799-5819, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28951094
8.
Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A1 receptor antagonists and their biological evaluation.
Bioorg Med Chem
; 25(6): 1963-1975, 2017 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28238512
9.
Impact of APCI ionization source in liquid chromatography tandem mass spectrometry based tissue distribution studies.
Biomed Chromatogr
; 30(10): 1676-85, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-27079144
10.
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase.
Bioorg Med Chem Lett
; 22(13): 4341-7, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22658862
11.
Discovery of a potent and selective small molecule hGPR91 antagonist.
Bioorg Med Chem Lett
; 21(12): 3596-602, 2011 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21571530
12.
Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.
Endocrinology
; 148(1): 4-12, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17008401
13.
Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.
Diabetes
; 55(1): 240-8, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16380499
14.
Discovery of Potent and Selective A2A Antagonists with Efficacy in Animal Models of Parkinson's Disease and Depression.
ACS Med Chem Lett
; 8(8): 835-840, 2017 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28835798
15.
A2B adenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives.
Eur J Med Chem
; 127: 986-996, 2017 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27842891
16.
Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia.
Eur J Med Chem
; 133: 268-286, 2017 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-28390958
17.
Design and synthesis of novel xanthine derivatives as potent and selective A2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases.
Eur J Med Chem
; 134: 218-229, 2017 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28415011
18.
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation.
J Med Chem
; 60(2): 681-694, 2017 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-28055204
19.
Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats.
ACS Med Chem Lett
; 2(12): 919-23, 2011 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900281
20.
A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARalpha/gamma activator.
Anal Biochem
; 363(2): 263-74, 2007 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17335769