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1.
Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect Against Amyloid ß-Induced Neurotoxicity in Primary Rat Neurons.
Int J Mol Sci
; 22(20)2021 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34681742
2.
Discovery of 5-methyl-N-(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors.
J Enzyme Inhib Med Chem
; 35(1): 1110-1115, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32338093
3.
Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives as a novel selective inhibitor scaffold of JNK3.
J Enzyme Inhib Med Chem
; 35(1): 372-376, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31856610
4.
Discovery of 1-Pyrimidinyl-2-Aryl-4,6-Dihydropyrrolo [3,4-d]Imidazole-5(1H)-Carboxamide as a Novel JNK Inhibitor.
Int J Mol Sci
; 21(5)2020 Mar 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32131443
5.
Design, synthesis, and in vitro evaluation of N-(3-(3-alkyl-1H-pyrazol-5-yl) phenyl)-aryl amide for selective RAF inhibition.
Bioorg Med Chem Lett
; 29(4): 534-538, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30630714
6.
Conformational restriction of a type II FMS inhibitor leading to discovery of 5-methyl-N-(2-aryl-1H-benzo[d]imidazo-5-yl)isoxazole-4-carboxamide analogues as selective FLT3 inhibitors.
J Enzyme Inhib Med Chem
; 34(1): 1716-1721, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31571509
7.
Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor.
J Enzyme Inhib Med Chem
; 34(1): 1314-1320, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31307243
8.
Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases.
Eur J Med Chem
; 245(Pt 1): 114917, 2023 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36395646
9.
Carbamate JNK3 Inhibitors Show Promise as Effective Treatments for Alzheimer's Disease: In Vivo Studies on Mouse Models.
J Med Chem
; 66(9): 6372-6390, 2023 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37094094
10.
Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease.
Eur J Med Chem
; 245(Pt 1): 114894, 2023 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36343411
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