Detalles de la búsqueda
1.
Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats.
Regul Toxicol Pharmacol
; 92: 382-389, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29278695
2.
Point of departure (PoD) selection for the derivation of acceptable daily exposures (ADEs) for active pharmaceutical ingredients (APIs).
Regul Toxicol Pharmacol
; 79 Suppl 1: S48-56, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-27233925
3.
Using default methodologies to derive an acceptable daily exposure (ADE).
Regul Toxicol Pharmacol
; 79 Suppl 1: S28-38, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-27233926
4.
Determination of GDC-0980 (apitolisib), a small molecule dual phosphatidylinositide 3-kinase/mammalian target of rapamycin inhibitor in dog plasma by LC-MS/MS to support a GLP toxicology study.
Biomed Chromatogr
; 29(8): 1274-9, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25677784
5.
Embryofetal development study of vismodegib, a hedgehog pathway inhibitor, in rats.
Birth Defects Res B Dev Reprod Toxicol
; 101(2): 135-43, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24692404
6.
Development of Duration-Based Non-Mutagenic Thresholds of Toxicological Concern (TTCs) Relevant to Parenteral Extractables and Leachables (E&Ls).
PDA J Pharm Sci Technol
; 76(5): 369-383, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35031541
7.
Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling.
Drug Metab Dispos
; 38(7): 1029-38, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20406853
8.
Differential induction of N(2),3-ethenoguanine in rat brain and liver after exposure to vinyl chloride.
Cancer Res
; 62(18): 5183-8, 2002 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12234982
9.
Molecular dosimetry and repair of N(2),3-ethenoguanine in rats exposed to vinyl chloride.
Cancer Res
; 62(18): 5189-95, 2002 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12234983
10.
Methods for measuring DNA adducts and abasic sites I: isolation, purification, and analysis of DNA adducts in intact DNA.
Curr Protoc Toxicol
; Chapter 3: Unit3.8, 2002 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23045079
11.
The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene.
Regul Toxicol Pharmacol
; 37(1): 105-32, 2003 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-12662914
12.
Methods for measuring DNA adducts and abasic sites II: methods for measurement of DNA adducts.
Curr Protoc Toxicol
; Chapter 3: Unit3.9, 2002 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23045080
Resultados
1 -
12
de 12
1
Próxima >
>>