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1.
Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains.
J Infect Chemother
; 28(3): 377-383, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-34836778
2.
Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors.
Bioorg Med Chem
; 27(8): 1683-1692, 2019 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30878193
3.
Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor.
Bioorg Med Chem
; 27(6): 1056-1064, 2019 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30755348
4.
Discovery and Biological Evaluation of Potent and Orally Active Human 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes Mellitus.
Chem Pharm Bull (Tokyo)
; 67(8): 824-838, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31366832
5.
Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.
Bioorg Med Chem
; 26(18): 4971-4983, 2018 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30145050
6.
Optimization and in vivo evaluation of pyrazolopyridines as a potent and selective PI3Kδ inhibitor.
Bioorg Med Chem
; 26(14): 3917-3924, 2018 08 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29907471
7.
Discovery and biological evaluation of novel pyrazolopyridine derivatives as potent and orally available PI3Kδ inhibitors.
Bioorg Med Chem
; 26(9): 2410-2419, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29631787
8.
Synthesis and pharmacological evaluation of glycine amide derivatives as novel vascular adhesion protein-1 inhibitors without CYP3A4 and CYP2C19 inhibition.
Bioorg Med Chem
; 25(15): 4110-4122, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28601507
9.
Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors.
Bioorg Med Chem
; 25(1): 187-201, 2017 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27810440
10.
Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors.
Bioorg Med Chem
; 25(20): 5311-5326, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28789911
11.
Design, synthesis, and evaluation of 4,6-diaminonicotinamide derivatives as novel and potent immunomodulators targeting JAK3.
Bioorg Med Chem
; 24(19): 4711-4722, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27544589
12.
Discovery of 3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one derivatives as novel JAK inhibitors.
Bioorg Med Chem
; 23(15): 4846-4859, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26059596
13.
Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3.
Bioorg Med Chem
; 23(15): 4871-4883, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26071372
14.
Synthesis and evaluation of 1H-pyrrolo[2,3-b]pyridine derivatives as novel immunomodulators targeting Janus kinase 3.
Chem Pharm Bull (Tokyo)
; 63(5): 341-53, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25786493
15.
Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists.
Bioorg Med Chem
; 22(21): 6026-38, 2014 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25281269
16.
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists.
Bioorg Med Chem
; 22(13): 3478-87, 2014 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24837158
17.
Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2.
Bioorg Med Chem
; 22(15): 4323-37, 2014 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24916029
18.
Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment.
Bioorg Med Chem
; 21(13): 3873-81, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23664164
19.
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema.
Bioorg Med Chem
; 21(5): 1219-33, 2013 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23337801
20.
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema: part 2.
Bioorg Med Chem
; 21(9): 2478-94, 2013 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23540955