Detalles de la búsqueda
1.
Non-clinical, quality and environmental impact assessments of cell and gene therapy products: Report on the 5th Asia Partnership Conference of Regenerative Medicine - April 7, 2022.
Cytotherapy
; 25(7): 683-698, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37097265
2.
Nonclinical and quality assessment of cell therapy products: Report on the 4th Asia Partnership Conference of Regenerative Medicine, April 15, 2021.
Cytotherapy
; 24(9): 892-904, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35193824
3.
Non-clinical assessment of cell therapy products: the perspective from five Asian countries/regions based on regulatory guidelines and the underpinning rationales.
Cytotherapy
; 23(10): 874-885, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34116946
4.
Pharmacokinetic and pharmacodynamic modeling of the metastin/kisspeptin analog, TAK-448, for its anti-tumor efficacy in a rat xenograft model.
Biopharm Drug Dispos
; 41(7): 283-294, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-32562504
5.
The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats.
Drug Metab Dispos
; 47(9): 1004-1012, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31201213
6.
Characterization of Fasiglifam-Related Liver Toxicity in Dogs.
Drug Metab Dispos
; 47(5): 525-534, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30765394
7.
Investigation of disposition for TAK-448, a synthetic peptide of kisspeptin analog, in rats and dogs using the radiolabeled TAK-448 suitable for pharmacokinetic study.
Xenobiotica
; 49(7): 833-839, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-30044673
8.
Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans.
Xenobiotica
; 49(4): 433-445, 2019 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-29557709
9.
Influence of the pharmacokinetic profile on the plasma glucose lowering effect of the PPARγ agonist pioglitazone in Wistar fatty rats.
Biopharm Drug Dispos
; 38(6): 381-388, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28294376
10.
Impact of acute fat mobilisation on the pharmacokinetics of the highly fat distributed compound TAK-357, investigated by physiologically based pharmacokinetic (PBPK) modeling and simulation.
Biopharm Drug Dispos
; 38(6): 373-380, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28256717
11.
Influence of body composition on disposition of the highly fat distributed compound as analysed by physiologically based pharmacokinetic (PBPK) modeling and simulation.
Biopharm Drug Dispos
; 38(9): 543-552, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28948605
12.
DMPK perspective on quantitative model analysis for chimeric antigen receptor cell therapy: Advances and challenges.
Drug Metab Pharmacokinet
; 56: 101003, 2024 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38843652
13.
Peginesatide clearance, distribution, metabolism, and excretion in monkeys following intravenous administration.
Drug Metab Dispos
; 41(4): 774-84, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23318685
14.
Species differences of organic anion transporters involved in the renal uptake of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, between rats and dogs.
Biopharm Drug Dispos
; 34(4): 236-46, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23529922
15.
Development and validation of qPCR methods for nucleic acid biomarkers as a drug development tool: points to consider.
Bioanalysis
; 15(17): 1069-1081, 2023 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-37584367
16.
Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats.
Xenobiotica
; 42(7): 660-70, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22188389
17.
Biodistribution studies for cell therapy products: Current status and issues.
Regen Ther
; 18: 202-216, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34307798
18.
Development of a bioanalytical method for circulating human T cells in animals using Arthrobacter luteus-based quantitative polymerase chain reaction and its application in preclinical biodistribution studies.
Regen Ther
; 15: 251-257, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-33426226
19.
Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells.
Sci Rep
; 10(1): 17884, 2020 10 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-33087808
20.
Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury.
Toxicol Sci
; 157(1): 50-61, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28108665