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1.
Trilaciclib prior to chemotherapy and atezolizumab in patients with newly diagnosed extensive-stage small cell lung cancer: A multicentre, randomised, double-blind, placebo-controlled Phase II trial.
Int J Cancer
; 148(10): 2557-2570, 2021 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33348420
2.
Trilaciclib plus chemotherapy versus chemotherapy alone in patients with metastatic triple-negative breast cancer: a multicentre, randomised, open-label, phase 2 trial.
Lancet Oncol
; 20(11): 1587-1601, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31575503
3.
A phase I, open-label, two-stage study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral AKT inhibitor GSK2141795 in patients with solid tumors.
Invest New Drugs
; 36(6): 1016-1025, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29611022
4.
A phase IIa study of afuresertib, an oral pan-AKT inhibitor, in patients with Langerhans cell histiocytosis.
Pediatr Blood Cancer
; 64(5)2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27804235
5.
The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma.
Blood
; 124(14): 2190-5, 2014 Oct 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-25075128
6.
Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial.
Lancet Oncol
; 13(8): 773-81, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22805291
7.
Effects of Trilaciclib on Chemotherapy-Induced Myelosuppression and Patient-Reported Outcomes in Patients with Extensive-Stage Small Cell Lung Cancer: Pooled Results from Three Phase II Randomized, Double-Blind, Placebo-Controlled Studies.
Clin Lung Cancer
; 22(5): 449-460, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33895103
8.
Myelopreservation with Trilaciclib in Patients Receiving Topotecan for Small Cell Lung Cancer: Results from a Randomized, Double-Blind, Placebo-Controlled Phase II Study.
Adv Ther
; 38(1): 350-365, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33123968
9.
Trilaciclib prior to chemotherapy reduces the usage of supportive care interventions for chemotherapy-induced myelosuppression in patients with small cell lung cancer: Pooled analysis of three randomized phase 2 trials.
Cancer Med
; 10(17): 5748-5756, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34405547
10.
Trastuzumab and beyond: New possibilities for the treatment of HER2-positive breast cancer.
Oncology (Williston Park)
; 20(14): 1763-71; discussion 1771-2, 1774-6, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17263127
11.
Acute liver failure due to natural killer-like T-cell leukemia/lymphoma: a case report and review of the literature.
World J Gastroenterol
; 12(25): 4089-92, 2006 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16810767
12.
First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies.
Clin Cancer Res
; 22(8): 1932-9, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26603258
13.
A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.
Oncotarget
; 6(39): 41736-49, 2015 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26497682
14.
Dose-Finding Quantitative 18F-FDG PET Imaging Study with the Oral Pan-AKT Inhibitor GSK2141795 in Patients with Gynecologic Malignancies.
J Nucl Med
; 56(12): 1828-35, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26429956
15.
Effect of casopitant, a novel NK-1 receptor antagonist, on the pharmacokinetics and pharmacodynamics of steady-state warfarin.
J Clin Pharmacol
; 50(5): 566-75, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20220045
16.
Molecular profiling in breast cancer.
Rev Endocr Metab Disord
; 8(3): 185-98, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17464566
17.
Gene expression profiling in breast cancer.
Curr Opin Oncol
; 19(6): 547-51, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17906450
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