Detalles de la búsqueda
1.
Mechanistic account of distinct change in organic anion transporting polypeptide 1B (OATP1B) substrate pharmacokinetics during OATP1B-mediated drug-drug interactions using physiologically-based pharmacokinetic modeling.
Drug Metab Dispos
; 2024 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38740464
2.
Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.
Drug Metab Dispos
; 48(2): 93-105, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31771949
3.
Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance.
Drug Metab Dispos
; 47(3): 215-226, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30593544
4.
Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters.
Mol Pharm
; 14(1): 310-318, 2017 01 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27977217
5.
Effect of chronic γ-hydroxybutyrate (GHB) administration on GHB toxicokinetics and GHB-induced respiratory depression.
Am J Drug Alcohol Abuse
; 43(6): 686-693, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28662343
6.
Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events.
Kidney Int
; 89(5): 1144-1152, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-27083288
7.
Is personalized medicine a dream or a reality?
Crit Rev Clin Lab Sci
; 52(1): 1-11, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25181036
8.
Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.
Drug Metab Dispos
; 43(7): 984-93, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25904762
9.
Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake.
Drug Metab Dispos
; 43(11): 1788-94, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26341276
10.
A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose.
Pharm Res
; 32(6): 1894-906, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25480120
11.
Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease.
Dig Dis Sci
; 60(12): 3620-30, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26160437
12.
Toxicokinetics/Toxicodynamics of γ-hydroxybutyrate-ethanol intoxication: evaluation of potential treatment strategies.
J Pharmacol Exp Ther
; 346(3): 504-13, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23814094
13.
Effects of monocarboxylate transporter inhibition on the oral toxicokinetics/toxicodynamics of γ-hydroxybutyrate and γ-butyrolactone.
J Pharmacol Exp Ther
; 345(1): 102-10, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23392755
14.
Utilization of OATP1B Biomarker Coproporphyrin-I to Guide Drug-Drug Interaction Risk Assessment: Evaluation by the Pharmaceutical Industry.
Clin Pharmacol Ther
; 114(6): 1170-1183, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37750401
15.
γ-Hydroxybutyrate (GHB)-induced respiratory depression: combined receptor-transporter inhibition therapy for treatment in GHB overdose.
Mol Pharmacol
; 82(2): 226-35, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22561075
16.
γ-Hydroxybutyrate blood/plasma partitioning: effect of physiologic pH on transport by monocarboxylate transporters.
Drug Metab Dispos
; 40(1): 64-9, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21976619
17.
Physiologically based pharmacokinetic modeling of tadalafil to inform pediatric dose selection in children with pulmonary arterial hypertension.
CPT Pharmacometrics Syst Pharmacol
; 11(2): 173-184, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34800000
18.
Erratum to: Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease.
Dig Dis Sci
; 61(1): 325, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26233551
19.
γ-Hydroxybutyric Acid: Pharmacokinetics, Pharmacodynamics, and Toxicology.
AAPS J
; 23(1): 22, 2021 01 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33417072
20.
Comparison of Hepatic Transporter Tissue Expression in Rodents and Interspecies Hepatic OCT1 Activity.
AAPS J
; 23(3): 58, 2021 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33903987