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1.
Disease correction in mucopolysaccharidosis type IIIB mice by intraparenchymal or cisternal delivery of a capsid modified AAV8 codon-optimized NAGLU vector.
Hum Mol Genet
; 32(3): 417-430, 2023 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-35997776
2.
Biochemical signatures of disease severity in multiple sulfatase deficiency.
J Inherit Metab Dis
; 47(2): 374-386, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-37870986
3.
Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine-hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer.
J Enzyme Inhib Med Chem
; 36(1): 1290-1312, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34187263
4.
3D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: Design, synthesis and biological evaluation.
Bioorg Chem
; 89: 102988, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31146197
5.
Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma.
J Enzyme Inhib Med Chem
; 34(1): 1062-1077, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31072216
6.
Structure-guided development of covalent TAK1 inhibitors.
Bioorg Med Chem
; 25(3): 838-846, 2017 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28011204
7.
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
Bioorg Med Chem
; 25(4): 1320-1328, 2017 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28038940
8.
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives.
Bioorg Med Chem
; 24(16): 3501-12, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27288180
9.
Lead generation of UPPS inhibitors targeting MRSA: Using 3D-QSAR pharmacophore modeling, virtual screening, molecular docking, and molecular dynamic simulations.
BMC Chem
; 18(1): 14, 2024 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38245752
10.
Camptothecin structure simplification elaborated new imidazo[2,1-b]quinazoline derivative as a human topoisomerase I inhibitor with efficacy against bone cancer cells and colon adenocarcinoma.
Eur J Med Chem
; 265: 116049, 2024 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38185054
11.
Lead generation of cysteine based mesenchymal epithelial transition (c-Met) kinase inhibitors: Using structure-based scaffold hopping, 3D-QSAR pharmacophore modeling, virtual screening, molecular docking, and molecular dynamics simulation.
Comput Biol Med
; 146: 105526, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35487125
12.
Structural Basis of Selective Human Indoleamine-2,3-dioxygenase 1 (hIDO1) Inhibition.
ChemMedChem
; 16(20): 3149-3164, 2021 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34174026
13.
Design, synthesis and in vitro anti-proliferative activity of 4,6-quinazolinediamines as potent EGFR-TK inhibitors.
Eur J Med Chem
; 61: 132-45, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23142066
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