Detalles de la búsqueda
1.
A phase Ib study of adavosertib, a selective Wee1 inhibitor, in patients with locally advanced or metastatic solid tumors.
Invest New Drugs
; 41(3): 493-502, 2023 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-37171722
2.
Comprehensive clinical pharmacology characterization of AZD4635 in healthy participants to support dosing considerations.
Br J Clin Pharmacol
; 89(9): 2775-2787, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37055936
3.
Population pharmacokinetic analysis of danvatirsen supporting flat dosing switch.
J Pharmacokinet Pharmacodyn
; 46(1): 65-74, 2019 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-30661177
4.
Longitudinal Circulating Tumor DNA Modeling to Predict Disease Progression in First-Line Mutant Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer.
Clin Pharmacol Ther
; 115(2): 349-360, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38010260
5.
Development of a multiscale mechanistic modeling framework integrating differential cellular kinetics of CAR T-cell subsets and immunophenotypes in cancer patients.
CPT Pharmacometrics Syst Pharmacol
; 12(9): 1285-1304, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37448297
6.
Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 92(3): 193-203, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37394627
7.
Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study.
Cancer Chemother Pharmacol
; 92(2): 141-150, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37368100
8.
A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors.
Target Oncol
; 18(4): 517-530, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37278879
9.
Assessment of the impact of CYP3A polymorphisms on the formation of α-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes.
Drug Metab Dispos
; 40(2): 389-96, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22096084
10.
Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR.
Biopharm Drug Dispos
; 33(4): 207-17, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22498895
11.
Association between immune-mediated adverse events and efficacy in metastatic non-small-cell lung cancer patients treated with durvalumab and tremelimumab.
Front Immunol
; 13: 1026964, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36405729
12.
Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study.
Clin Cancer Res
; 28(1): 36-44, 2022 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34645648
13.
Pharmacokinetics of Lorlatinib After Single and Multiple Dosing in Patients with Anaplastic Lymphoma Kinase (ALK)-Positive Non-Small Cell Lung Cancer: Results from a Global Phase I/II Study.
Clin Pharmacokinet
; 60(10): 1313-1324, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33937954
14.
Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model.
Front Immunol
; 12: 617316, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33737925
15.
Safety, Antitumor Activity, and Biomarker Analysis in a Phase I Trial of the Once-daily Wee1 Inhibitor Adavosertib (AZD1775) in Patients with Advanced Solid Tumors.
Clin Cancer Res
; 27(14): 3834-3844, 2021 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33863809
16.
Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis.
Oncoimmunology
; 9(1): 1748982, 2020 05 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32934874
17.
Effect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 86(1): 97-108, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32556602
18.
Safety, Pharmacokinetics, and Clinical Activity of Adavosertib in Combination with Chemotherapy in Asian Patients with Advanced Solid Tumors: Phase Ib Study.
Target Oncol
; 15(1): 75-84, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32034630
19.
Food Effect Study Design With Oral Drugs: Lessons Learned From Recently Approved Drugs in Oncology.
J Clin Pharmacol
; 59(4): 463-471, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30536979
20.
Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
Drug Metab Dispos
; 36(6): 1172-80, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18332086