Detalles de la búsqueda
1.
Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies.
Biotechnol Bioeng
; 109(12): 3172-81, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22688505
2.
Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project.
Altern Lab Anim
; 39(2): 147-71, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21639679
3.
Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model.
Toxicology
; 448: 152637, 2021 01 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-33220337
4.
Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models.
Toxicol In Vitro
; 72: 105051, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-33188879
5.
An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells.
Toxicol Appl Pharmacol
; 237(2): 221-31, 2009 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19332084
6.
Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study.
Toxicol In Vitro
; 60: 212-228, 2019 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-31158489
7.
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
J Med Chem
; 51(7): 2158-69, 2008 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18324762
8.
Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17.
Bioorg Med Chem Lett
; 18(1): 267-73, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18024111
9.
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.
Bioorg Med Chem
; 16(16): 7715-27, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18674917
10.
Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.
Bioorg Med Chem
; 16(4): 1992-2010, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18061460
11.
CYP17 inhibitors. Annulations of additional rings in methylene imidazole substituted biphenyls: synthesis, biological evaluation and molecular modelling.
Arch Pharm (Weinheim)
; 341(10): 597-609, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18720339
12.
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.
J Med Chem
; 49(7): 2222-31, 2006 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16570918
13.
Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.
J Med Chem
; 48(5): 1563-75, 2005 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-15743198
14.
Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.
J Med Chem
; 48(21): 6632-42, 2005 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-16220979
15.
Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.
J Med Chem
; 48(6): 1796-805, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771425
16.
The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors.
J Steroid Biochem Mol Biol
; 96(3-4): 259-70, 2005 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-15985365
17.
Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies.
J Tissue Eng Regen Med
; 9(9): 1017-26, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23165723
18.
Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure.
Eur J Pharm Sci
; 45(5): 716-24, 2012 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-22330146
19.
In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor.
J Tissue Eng Regen Med
; 5(8): e207-18, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21442764
20.
HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro.
J Pharmacol Toxicol Methods
; 63(1): 59-68, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-20460162