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1.
Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 56(6): 3324-35, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22391531
2.
Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase.
Bioorg Med Chem Lett
; 21(24): 7344-50, 2011 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22071300
3.
Purification of untagged HIV-1 reverse transcriptase by affinity chromatography.
Protein Expr Purif
; 71(2): 231-9, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20060474
4.
Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.
Bioorg Med Chem Lett
; 20(15): 4328-32, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20609585
5.
Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 53(6): 2424-31, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19289522
6.
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
Bioorg Med Chem Lett
; 19(17): 5119-23, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19631528
7.
Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Bioorg Med Chem Lett
; 18(2): 554-9, 2008 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18083561
8.
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorg Med Chem Lett
; 18(9): 2959-66, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18396399
9.
Mechanistic Study of Common Non-Nucleoside Reverse Transcriptase Inhibitor-Resistant Mutations with K103N and Y181C Substitutions.
Viruses
; 8(10)2016 09 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27669286
10.
Screening of HIV-1 Protease Using a Combination of an Ultra-High-Throughput Fluorescent-Based Assay and RapidFire Mass Spectrometry.
J Biomol Screen
; 20(5): 606-15, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25681434
11.
Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.
J Med Chem
; 57(13): 5800-16, 2014 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24914455
12.
Design, synthesis, and X-ray crystallographic analysis of a novel class of HIV-1 protease inhibitors.
J Med Chem
; 54(20): 7176-83, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21916489
13.
Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase.
J Med Chem
; 54(22): 7920-33, 2011 Nov 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21985673
14.
Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses.
J Med Chem
; 52(22): 7163-9, 2009 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-19883100
15.
Monitoring the development of non-nucleoside reverse transcriptase inhibitor-associated resistant HIV-1 using an electrochemiluminescence-based reverse transcriptase polymerase assay.
Anal Biochem
; 374(1): 121-32, 2008 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17964275
16.
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
J Med Chem
; 51(20): 6503-11, 2008 Oct 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-18826204
17.
Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant.
Bioorg Med Chem Lett
; 16(10): 2748-52, 2006 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16503141
18.
Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.
Biochemistry
; 44(5): 1595-606, 2005 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-15683243
19.
Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid.
J Biol Chem
; 278(5): 2777-80, 2003 Jan 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-12480948
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