Detalles de la búsqueda
1.
N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
Bioorg Med Chem Lett
; 21(18): 5283-8, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21802943
2.
Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Bioorg Med Chem Lett
; 20(3): 1094-9, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20031401
3.
Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells.
Bioorg Med Chem Lett
; 20(3): 1100-5, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20022747
4.
Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors.
Bioorg Med Chem Lett
; 19(15): 4042-5, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19553107
5.
Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway.
Bioorg Med Chem Lett
; 19(15): 4191-5, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19540115
6.
Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.
Bioorg Med Chem Lett
; 19(15): 4196-200, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19541484
7.
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.
Bioorg Med Chem Lett
; 19(16): 4617-21, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616948
8.
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
J Med Chem
; 51(4): 861-74, 2008 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18217703
9.
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(23): 6083-7, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18930398
10.
Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.
Bioorg Med Chem Lett
; 18(23): 6078-82, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18952417
11.
Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.
J Med Chem
; 50(9): 2225-39, 2007 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-17428043
12.
Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
J Med Chem
; 50(20): 4953-75, 2007 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17824681
13.
4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.
J Med Chem
; 49(23): 6646-9, 2006 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-17154493
14.
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies.
J Med Chem
; 49(18): 5404-7, 2006 Sep 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16942012
15.
A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand.
Chem Biol
; 12(8): 883-93, 2005 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16125100
16.
Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.
J Med Chem
; 52(21): 6782-9, 2009 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-19888759
17.
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.
J Med Chem
; 51(18): 5843-55, 2008 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18763751
18.
(1)H, (13)C and (15)N backbone assignments for the ligand binding domain of the Pseudomonas aeruginosa virulence regulator LasR.
Biomol NMR Assign
; 1(2): 237-9, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19636874
19.
Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer.
J Biol Chem
; 282(18): 13592-600, 2007 May 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17363368
20.
Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant.
Bioorg Med Chem Lett
; 16(10): 2748-52, 2006 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16503141