Detalles de la búsqueda
1.
Mass Balance, Metabolic Pathways, Absolute Bioavailability, And Pharmacokinetics of Giredestrant In Healthy Subjects.
Drug Metab Dispos
; 2024 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38834357
2.
The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor.
Drug Metab Dispos
; 51(10): 1332-1341, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37524543
3.
Evaluation of Ipatasertib Interactions with Itraconazole and Coproporphyrin I and III in a Single Drug Interaction Study in Healthy Subjects.
J Pharmacol Exp Ther
; 378(2): 87-95, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34049965
4.
A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors.
Invest New Drugs
; 39(1): 163-174, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32737717
5.
Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models.
Drug Metab Dispos
; 48(12): 1264-1270, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33037044
6.
Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors.
Invest New Drugs
; 38(2): 419-432, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31020608
7.
Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis.
Lancet Oncol
; 19(3): 310-322, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29449192
8.
Correction to: Application of a Novel 'Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects.
Pharm Res
; 35(12): 244, 2018 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-30367284
9.
Application of a Novel 'Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects.
Pharm Res
; 35(12): 233, 2018 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30324422
10.
Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.
Drug Metab Dispos
; 44(1): 28-39, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26451002
11.
Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: a phase 1b study.
Lancet Oncol
; 15(9): 954-65, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25037139
12.
Absolute bioavailability and effect of formulation change, food, or elevated pH with rabeprazole on cobimetinib absorption in healthy subjects.
Mol Pharm
; 10(11): 4046-54, 2013 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-24010577
13.
A phase II multicenter study of two different dosages of pemetrexed given in combination with cyclophosphamide as first-line treatment in patients with locally advanced or metastatic breast cancer.
Cancer Invest
; 30(4): 309-16, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22468806
14.
Time to Rethink the Current Paradigm for Assessing Kidney Function in Drug Development and Beyond.
Clin Pharmacol Ther
; 112(5): 946-958, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34800044
15.
Assessment of cytochrome P450 3A4-mediated drug-drug interactions for ipatasertib using a fit-for-purpose physiologically based pharmacokinetic model.
Cancer Chemother Pharmacol
; 89(5): 707-720, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35428895
16.
Pharmacokinetics of Ipatasertib in Subjects With Hepatic Impairment Using 2 Methods of Classification of Hepatic Function.
J Clin Pharmacol
; 62(2): 171-181, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34402068
17.
Cobimetinib in Pediatric and Young Adult Patients with Relapsed or Refractory Solid Tumors (iMATRIX-cobi): A Multicenter, Phase I/II Study.
Target Oncol
; 17(3): 283-293, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35715627
18.
Single- and multiple-dose pharmacokinetics, potential for CYP3A inhibition, and food effect in patients with cancer and healthy subjects receiving ipatasertib.
Cancer Chemother Pharmacol
; 88(6): 921-930, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34471960
19.
Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics.
Clin Pharmacol Drug Dev
; 10(2): 144-152, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32696585
20.
Phase I and pharmacokinetic study of pemetrexed plus cisplatin in chemonaive patients with locally advanced or metastatic malignant pleural mesothelioma or non-small cell lung cancer.
Clin Cancer Res
; 15(1): 382-9, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19118069