Detalles de la búsqueda
1.
Natural products as IL-6 inhibitors for inflammatory diseases: Synthetic and SAR perspective.
Med Res Rev
; 44(4): 1683-1726, 2024 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-38305581
2.
Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure-Activity Relationship (SAR).
Int J Mol Sci
; 24(11)2023 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-37298401
3.
Integration of Hybridization Strategies in Pyridine-Urea Scaffolds for Novel Anticancer Agents: Design, Synthesis, and Mechanistic Insights.
Molecules
; 28(13)2023 Jun 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-37446614
4.
4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies.
J Enzyme Inhib Med Chem
; 37(1): 994-1004, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35350942
5.
Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies.
Int J Mol Sci
; 23(5)2022 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35269684
6.
The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer.
Int J Mol Sci
; 22(12)2021 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34207360
7.
Structure Activity Relationship of Key Heterocyclic Anti-Angiogenic Leads of Promising Potential in the Fight against Cancer.
Molecules
; 26(3)2021 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-33494492
8.
Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails.
J Enzyme Inhib Med Chem
; 33(1): 629-638, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29536779
9.
PT-Finder: A multi-modal neural network approach to target identification.
Comput Biol Med
; 174: 108444, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38636325
10.
Discovery and optimization of natural-based nanomolar c-Kit inhibitors via in silico and in vitro studies.
J Biomol Struct Dyn
; 41(21): 11904-11915, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36636795
11.
Identification of Potent hDHODH Inhibitors for Lung Cancer via Virtual Screening of a Rationally Designed Small Combinatorial Library.
ACS Omega
; 8(24): 21769-21780, 2023 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37360481
12.
Cantharidin-Based Verbenone Derivatives as a Novel Insecticide against Plutella xylostella: Design, Synthesis, Insecticidal Activity Evaluation, and 3D QSAR Study.
Biomolecules
; 13(8)2023 08 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-37627337
13.
Perspective for Discovery of Small Molecule IL-6 Inhibitors through Study of Structure-Activity Relationships and Molecular Docking.
J Med Chem
; 66(7): 4417-4433, 2023 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36971365
14.
Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast Cancer-Design, Synthesis, and In Vitro Evaluation.
ACS Omega
; 8(35): 31784-31800, 2023 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37692247
15.
Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment.
Pharmaceuticals (Basel)
; 16(5)2023 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37242466
16.
Identification of 1H-purine-2,6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations.
PeerJ
; 10: e14120, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36225900
17.
Identification of novel discoidin domain receptor 1 (DDR1) inhibitors using E-pharmacophore modeling, structure-based virtual screening, molecular dynamics simulation and MM-GBSA approaches.
Comput Biol Med
; 142: 105217, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35032738
18.
Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling.
Eur J Med Chem
; 242: 114692, 2022 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36029560
19.
Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity.
Biomedicines
; 9(9)2021 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34572319
20.
Hit Identification of a Novel Quinazoline Sulfonamide as a Promising EphB3 Inhibitor: Design, Virtual Combinatorial Library, Synthesis, Biological Evaluation, and Docking Simulation Studies.
Pharmaceuticals (Basel)
; 14(12)2021 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-34959648