Detalles de la búsqueda
1.
Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk assessment of epyrifenacil.
Toxicol Appl Pharmacol
; 465: 116439, 2023 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36858113
2.
Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver.
Toxicol Appl Pharmacol
; 439: 115912, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35143805
3.
Flumioxazin metabolism in pregnant animals and cell-based protoporphyrinogen IX oxidase (PPO) inhibition assay of fetal metabolites in various animal species to elucidate the mechanism of the rat-specific developmental toxicity.
Toxicol Appl Pharmacol
; 339: 34-41, 2018 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29198728
4.
Metabolism of metofluthrin in rats: I. Identification of metabolites.
Xenobiotica
; 48(2): 157-169, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28092216
5.
Metabolism of metofluthrin in rats: II. Excretion, distribution and amount of metabolites.
Xenobiotica
; 48(11): 1113-1127, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-29157071
6.
Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile.
J Proteome Res
; 16(10): 3634-3645, 2017 10 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28825834
7.
Identification and in silico prediction of metabolites of the model compound, tebufenozide by human CYP3A4 and CYP2C19.
Bioorg Med Chem
; 23(20): 6594-601, 2015 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26404412
8.
Quantitative structure-activity relationship model for the fetal-maternal blood concentration ratio of chemicals in humans.
Biol Pharm Bull
; 38(6): 930-4, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26027836
9.
Metabolism and physiologically based pharmacokinetic modeling of flumioxazin in pregnant animals.
Toxicol Appl Pharmacol
; 277(3): 242-9, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24717917
10.
Metabolism of propyrisulfuron: 14C excretion, 14C concentration in plasma and tissues, and amount of metabolites in rats.
Xenobiotica
; 44(10): 882-92, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24661045
11.
Metabolism of 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether (pyridalyl) in rats after repeated oral administration and a simple physiologically based pharmacokinetic modeling in brown and white adipose tissues.
Drug Metab Dispos
; 38(5): 824-32, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20164113
12.
Circulating natural antibodies against 3'-sialyllactose complement the diagnostic performance of CA19-9 for the early detection of pancreatic ductal adenocarcinoma.
Cancer Biomark
; 27(1): 121-128, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-31771041
13.
Metabolism of pyridalyl in rats.
Drug Metab Dispos
; 37(12): 2284-9, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19773539
14.
Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes.
Toxicology
; 258(1): 64-9, 2009 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-19378387
15.
Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse.
Toxicol Sci
; 168(2): 572-596, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30629241
16.
Species differences in the developmental toxicity of procymidone-Placental transfer of procymidone in pregnant rats, rabbits, and monkeys.
J Pestic Sci
; 43(2): 79-87, 2018 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-30363091
17.
Editor's Highlight: Development of Novel Neural Embryonic Stem CellTests for High-Throughput Screening of Embryotoxic Chemicals.
Toxicol Sci
; 159(1): 238-250, 2017 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28903496
18.
Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes.
Toxicol Sci
; 158(2): 412-430, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28520973
19.
Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates.
Toxicol Lett
; 259: 44-51, 2016 Sep 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-27444379
20.
Hand1-Luc embryonic stem cell test (Hand1-Luc EST): a novel rapid and highly reproducible in vitro test for embryotoxicity by measuring cytotoxicity and differentiation toxicity using engineered mouse ES cells.
J Toxicol Sci
; 40(2): 251-61, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25786529