Detalles de la búsqueda
1.
Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands.
Bioorg Med Chem Lett
; 99: 129611, 2024 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38228254
2.
Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5trioxazatriquinane skeleton.
Bioorg Med Chem Lett
; 82: 129151, 2023 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36690040
3.
Role for µ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127.
J Pharmacol Sci
; 151(3): 135-141, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-36828615
4.
Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives.
Bioorg Med Chem Lett
; 59: 128550, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35041942
5.
Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors.
Bioorg Med Chem Lett
; 59: 128527, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35007722
6.
Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.
Bioorg Med Chem Lett
; 59: 128530, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35007725
7.
Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands.
Bioorg Med Chem Lett
; 56: 128485, 2022 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34861349
8.
Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring.
Bioorg Med Chem Lett
; 60: 128555, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35051577
9.
Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors.
Bioorg Med Chem
; 53: 116552, 2022 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34894610
10.
Cold-Restraint Stress-Induced Ultrasonic Vocalization as a Novel Tool to Measure Anxiety in Mice.
Biol Pharm Bull
; 45(3): 268-275, 2022 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35046246
11.
Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice.
Biochem Biophys Res Commun
; 560: 192-198, 2021 06 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-34000468
12.
Regulatory expression of uncoupling protein 1 and its related genes by endogenous activity of the transforming growth factor-ß family in bovine myogenic cells.
Cell Biochem Funct
; 39(1): 116-125, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-33006416
13.
Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.
Bioorg Med Chem Lett
; 30(17): 127360, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32738987
14.
Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.
Bioorg Med Chem Lett
; 30(3): 126893, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31879208
15.
Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.
Proc Natl Acad Sci U S A
; 114(22): 5731-5736, 2017 05 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-28507129
16.
Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities.
Molecules
; 25(5)2020 Mar 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32131542
17.
In silico design of novel probes for the atypical opioid receptor MRGPRX2.
Nat Chem Biol
; 13(5): 529-536, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28288109
18.
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.
Bioorg Med Chem Lett
; 29(18): 2655-2658, 2019 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31375290
19.
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.
Bioorg Med Chem
; 27(8): 1747-1758, 2019 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30871861
20.
Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats.
J Pharmacol Sci
; 139(3): 174-179, 2019 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-30686587