Detalles de la búsqueda
1.
A Novel and Highly Potent Urotensin II Receptor Antagonist Inhibits Urotensin II-Induced Pressure Response in Mice.
J Cardiovasc Pharmacol
; 73(1): 15-21, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30608334
2.
Pharmacokinetic and Pharmacodynamic Profiles of Glyco-Modified Atrial Natriuretic Peptide Derivatives Synthesized Using Chemo-enzymatic Synthesis Approaches.
Bioconjug Chem
; 29(8): 2829-2837, 2018 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30107743
3.
Sustained Activation of Guanylate Cyclase-A with TDT, a Natriuretic Peptide Derivative, Exhibits Cardiorenal Protection in Dahl Salt-Sensitive Hypertensive Rats.
J Pharmacol Exp Ther
; 363(3): 402-410, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29021382
4.
Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists.
Bioorg Med Chem Lett
; 27(21): 4904-4907, 2017 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28958620
5.
Three classical Cepheid variable stars in the nuclear bulge of the Milky Way.
Nature
; 477(7363): 188-90, 2011 Aug 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21866100
6.
Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling.
Circulation
; 126(8): 942-51, 2012 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22829024
7.
Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors.
Bioorg Med Chem
; 21(18): 5907-22, 2013 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23886807
8.
Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor.
Bioorg Med Chem
; 21(11): 3175-96, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23598247
9.
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
J Clin Invest
; 119(2): 408-20, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19127022
10.
Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload.
Circ Res
; 106(1): 193-202, 2010 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-19910579
11.
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors.
Bioorg Med Chem Lett
; 22(14): 4561-6, 2012 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22726934
12.
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors.
Bioorg Med Chem Lett
; 22(24): 7677-82, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23122821
13.
A novel sphingosine-1-phosphate receptor 1 antagonist prevents the proliferation and relaxation of vascular endothelial cells by sphingosine-1-phosphate.
Biol Pharm Bull
; 33(9): 1500-5, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20823564
14.
The urotensin II receptor antagonist DS37001789 ameliorates mortality in pressure-overload mice with heart failure.
Heliyon
; 6(2): e03352, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-32055741
15.
Identification of novel Urotensin-II receptor antagonists with potent inhibition of U-II induced pressor response in mice.
Eur J Pharmacol
; 886: 173391, 2020 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32745605
16.
Pressure-overload magnitude-dependence of the anti-hypertrophic efficacy of PDE5A inhibition.
J Mol Cell Cardiol
; 46(4): 560-7, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19159628
17.
Mice lacking fat storage-inducing transmembrane protein 2 show improved profiles upon pressure overload-induced heart failure.
Heliyon
; 5(3): e01292, 2019 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-30923760
18.
Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation.
Circulation
; 116(21): 2399-408, 2007 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-17984378
19.
Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil.
J Pharmacol Exp Ther
; 326(2): 380-7, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18456872
20.
Phosphodiesterase regulation of nitric oxide signaling.
Cardiovasc Res
; 75(2): 303-14, 2007 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17467673