Detalles de la búsqueda
1.
The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms.
Physiol Rev
; 99(2): 1153-1222, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30724669
2.
Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations.
Hum Genomics
; 18(1): 61, 2024 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38863077
3.
The molecular basis of dapsone activation of CYP2C9-catalyzed nonsteroidal anti-inflammatory drug oxidation.
J Biol Chem
; 299(12): 105368, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37866634
4.
Binding of SEP-363856 within TAAR1 and the 5HT1A receptor: implications for the design of novel antipsychotic drugs.
Mol Psychiatry
; 27(1): 88-94, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34376825
5.
Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway.
Bioorg Med Chem
; 72: 116970, 2022 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36063653
6.
Binding of clozapine to the GABAB receptor: clinical and structural insights.
Mol Psychiatry
; 25(9): 1910-1919, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32203158
7.
Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and Their Inhibition.
Adv Exp Med Biol
; 1322: 63-95, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34258737
8.
Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity.
Mol Pharmacol
; 98(6): 710-718, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33008919
9.
Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen.
J Pharmacol Exp Ther
; 374(3): 438-451, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32554434
10.
Newly identified structures of trace-amine associated receptor-1 (TAAR1) will aid discovery of next generation neuropsychiatric drugs.
Mol Psychiatry
; 2024 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38326558
11.
Computational Prediction of the Site(s) of Metabolism and Binding Modes of Protein Kinase Inhibitors Metabolized by CYP3A4.
Drug Metab Dispos
; 47(6): 616-631, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30902802
12.
Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
Mol Psychiatry
; 28(5): 1839-1842, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36932159
13.
Letters to the Editor: Letter to the Editor regarding 'A challenge to the dopamine orthodoxy in schizophrenia'.
Aust N Z J Psychiatry
; 57(10): 1394-1395, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37465954
14.
Why does clozapine cause increased rebound psychosis and catatonia, compared to quetiapine?
Aust N Z J Psychiatry
; 56(1): 98, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33971722
15.
Warfarin resistance associated with genetic polymorphism of VKORC1: linking clinical response to molecular mechanism using computational modeling.
Pharmacogenet Genomics
; 26(1): 44-50, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26513304
16.
Cytochrome P450 structure-function: insights from molecular dynamics simulations.
Drug Metab Rev
; 48(3): 434-52, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27167388
17.
Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition.
Drug Metab Dispos
; 44(3): 378-88, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26669329
18.
A Fragment-Based Approach for the Computational Prediction of the Nonspecific Binding of Drugs to Hepatic Microsomes.
Drug Metab Dispos
; 44(11): 1794-1798, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27543205
19.
A novel function for UDP glycosyltransferase 8: galactosidation of bile acids.
Mol Pharmacol
; 87(3): 442-50, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25519837
20.
Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective.
Drug Metab Rev
; 47(3): 335-45, 2015 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26289097