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1.
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.
Bioorg Med Chem
; 25(15): 4175-4193, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28642028
2.
Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition.
Bioorg Med Chem
; 25(15): 4153-4162, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28622905
3.
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.
Bioorg Med Chem Lett
; 22(14): 4769-72, 2012 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22677317
4.
Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.
Bioorg Med Chem
; 19(21): 6261-73, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21975069
5.
Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.
Bioorg Med Chem
; 19(18): 5539-52, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21856163
6.
Mice lacking ghrelin receptors resist the development of diet-induced obesity.
J Clin Invest
; 115(12): 3564-72, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16322794
7.
Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors.
SLAS Discov
; 23(2): 154-163, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28846466
8.
Investigation of Fat Metabolism during Antiobesity Interventions by Magnetic Resonance Imaging and Spectroscopy.
Magn Reson Insights
; 7: 33-40, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25574137
9.
Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.
J Med Chem
; 55(5): 2353-66, 2012 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22309223
10.
Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.
J Med Chem
; 55(9): 4336-51, 2012 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22490048
11.
Characterization of a novel ghrelin cell reporter mouse.
Regul Pept
; 155(1-3): 91-8, 2009 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-19361544
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