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Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.
J Med Chem
; 47(10): 2405-8, 2004 May 06.
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en Inglés
| MEDLINE | ID: mdl-15115380
2.
Synthesis of mono- and difluoronaphthoic acids.
J Org Chem
; 67(4): 1171-7, 2002 Feb 22.
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en Inglés
| MEDLINE | ID: mdl-11846659
3.
Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family.
Bioorg Med Chem Lett
; 12(5): 795-8, 2002 Mar 11.
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en Inglés
| MEDLINE | ID: mdl-11859005
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