Detalles de la búsqueda
1.
A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin B.
Proc Natl Acad Sci U S A
; 119(32): e2208938119, 2022 08 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35930662
2.
Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.
Proc Natl Acad Sci U S A
; 118(25)2021 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34155147
3.
Total Synthesis of Gukulenin B via Sequential Tropolone Functionalizations.
J Am Chem Soc
; 144(11): 5190-5196, 2022 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35275627
4.
A Highly Convergent Total Synthesis of Norhalichondrin B.
J Am Chem Soc
; 143(49): 20970-20979, 2021 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34851106
5.
A Reverse Approach to the Total Synthesis of Halichondrin B.
J Am Chem Soc
; 143(24): 9267-9276, 2021 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-34105959
6.
Design, Synthesis, and Biological Investigation of Thailanstatin A and Spliceostatin D Analogues Containing Tetrahydropyran, Tetrahydrooxazine, and Fluorinated Structural Motifs.
J Org Chem
; 86(3): 2499-2521, 2021 02 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33417458
7.
Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.
J Org Chem
; 86(4): 3377-3421, 2021 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33544599
8.
Total Synthesis of the Monomeric Unit of Lomaiviticin A.
J Am Chem Soc
; 142(47): 20201-20207, 2020 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33186022
9.
Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics.
J Am Chem Soc
; 142(5): 2549-2561, 2020 02 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31976660
10.
Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates.
J Am Chem Soc
; 142(29): 12890-12899, 2020 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32662641
11.
Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole Analogues.
J Am Chem Soc
; 142(36): 15476-15487, 2020 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32852944
12.
Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine.
Nat Prod Rep
; 37(11): 1404-1435, 2020 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32319494
13.
Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues.
J Org Chem
; 85(5): 2865-2917, 2020 03 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32065746
14.
DNA Binding and Cleavage Modes of Shishijimicin A.
J Am Chem Soc
; 141(19): 7842-7852, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31050893
15.
Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues.
J Org Chem
; 84(1): 365-378, 2019 01 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30557504
16.
The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies.
Angew Chem Int Ed Engl
; 58(33): 11206-11241, 2019 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31012193
17.
Total Syntheses of Thailanstatins A-C, Spliceostatin D, and Analogues Thereof. Stereodivergent Synthesis of Tetrasubstituted Dihydro- and Tetrahydropyrans and Design, Synthesis, Biological Evaluation, and Discovery of Potent Antitumor Agents.
J Am Chem Soc
; 140(26): 8303-8320, 2018 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29943984
18.
Total Synthesis and Full Structural Assignment of Namenamicin.
J Am Chem Soc
; 140(26): 8091-8095, 2018 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29932325
19.
Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.
J Am Chem Soc
; 140(10): 3690-3711, 2018 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29381062
20.
Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents.
J Am Chem Soc
; 140(38): 12120-12136, 2018 09 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-30216054