Detalles de la búsqueda
1.
Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.
Xenobiotica
; 47(5): 382-393, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-27389028
2.
Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers.
Drug Metab Dispos
; 43(3): 309-16, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25504502
3.
Development of a novel system for estimating human intestinal absorption using Caco-2 cells in the absence of esterase activity.
Drug Metab Dispos
; 38(2): 323-31, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19923255
4.
Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy.
Circ Res
; 100(12): 1755-64, 2007 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17495227
5.
Absorption, distribution, and excretion of 14C-labeled tacrolimus (FK506) after a single or repeated ocular instillation in rabbits.
J Ocul Pharmacol Ther
; 24(3): 333-43, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18476802
6.
Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake.
Eur J Pharm Sci
; 125: 181-192, 2018 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30287410
7.
New formulation of chemical peeling agent: 30% salicylic acid in polyethylene glycol. Absorption and distribution of 14C-salicylic acid in polyethylene glycol applied topically to skin of hairless mice.
J Dermatol Sci
; 28(3): 211-8, 2002 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-11912008
8.
Effect of intestinal first-pass hydrolysis on the oral bioavailability of an ester prodrug of fexofenadine.
J Pharm Sci
; 101(9): 3264-74, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22628163
9.
Comprehensive quantitative and qualitative liquid chromatography-radioisotope-mass spectrometry analysis for safety testing of tolbutamide metabolites without standard samples.
J Pharm Sci
; 100(9): 4024-36, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21638282
10.
In vitro P-glycoprotein interactions and steady-state pharmacokinetic interactions between tolvaptan and digoxin in healthy subjects.
J Clin Pharmacol
; 51(5): 761-9, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20679500
11.
Possible protective role of pregnenolone-16 alpha-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis.
Eur J Pharmacol
; 636(1-3): 145-54, 2010 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20359477
12.
In vitro evaluation of cytochrome P450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice.
Drug Metab Pharmacokinet
; 25(6): 539-50, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20930422
13.
Cytochrome p450 expression of cultured rat small hepatocytes after long-term cryopreservation.
Drug Metab Dispos
; 34(10): 1667-71, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16868070
14.
Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates.
Bioorg Med Chem Lett
; 13(24): 4321-6, 2003 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-14643318
15.
Thiol-based SAHA analogues as potent histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 14(12): 3313-7, 2004 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15149697
16.
Use of ADME studies to confirm the safety of epsilon-polylysine as a preservative in food.
Regul Toxicol Pharmacol
; 37(2): 328-40, 2003 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-12726761
Resultados
1 -
16
de 16
1
Próxima >
>>