Detalles de la búsqueda
1.
The Metabolism and Disposition of Brepocitinib in Humans and Characterization of the Formation Mechanism of an Aminopyridine Metabolite.
Drug Metab Dispos
; 2024 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38719744
2.
Delineating the role of cooperativity in the design of potent PROTACs for BTK.
Proc Natl Acad Sci U S A
; 115(31): E7285-E7292, 2018 07 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-30012605
3.
In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes.
Drug Metab Dispos
; 48(12): 1350-1363, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33020067
4.
Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.
J Pharmacol Exp Ther
; 367(2): 322-334, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30135178
5.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 357-366, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29330219
6.
6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to ß-Estradiol.
Drug Metab Dispos
; 46(12): 1836-1846, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30194276
7.
Data Generated by Quantitative Liquid Chromatography-Mass Spectrometry Proteomics Are Only the Start and Not the Endpoint: Optimization of Quantitative Concatemer-Based Measurement of Hepatic Uridine-5'-Diphosphate-Glucuronosyltransferase Enzymes with Reference to Catalytic Activity.
Drug Metab Dispos
; 46(6): 805-812, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29581103
8.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 346-356, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29330218
9.
Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.
Drug Metab Dispos
; 46(7): 989-1000, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29720472
10.
Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity.
Drug Metab Dispos
; 45(10): 1102-1112, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28768682
11.
Novel Method to Predict In Vivo Liver-to-Plasma Kpuu for OATP Substrates Using Suspension Hepatocytes.
Drug Metab Dispos
; 45(5): 576-580, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28258068
12.
Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.
Drug Metab Dispos
; 45(7): 721-733, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28396527
13.
Determination of Unbound Partition Coefficient and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake.
Drug Metab Dispos
; 44(10): 1633-42, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27417179
14.
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg Med Chem Lett
; 25(22): 5352-6, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26411795
15.
Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.
Bioorg Med Chem
; 21(17): 5081-97, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23871442
16.
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
Bioorg Med Chem Lett
; 22(18): 5989-94, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22892121
17.
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
J Med Chem
; 65(22): 15000-15013, 2022 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36322383
18.
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.
J Med Chem
; 63(19): 10879-10896, 2020 10 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32809824
19.
A sensitive method for the quantitation of the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in plasma using microfluidics chromatography tandem MS.
Bioanalysis
; 10(5): 357-368, 2018 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29516741
20.
Attempting to Unmask the Inhibition of Sulfotransferase 1E1 in 17α-Ethinyl Estradiol Drug Interactions.
J Clin Pharmacol
; 63(8): 875-879, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36919596