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1.
The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia.
Blood
; 142(7): 629-642, 2023 08 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37172201
2.
Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
Angew Chem Int Ed Engl
; 60(51): 26663-26670, 2021 12 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34614283
3.
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold.
Bioorg Med Chem Lett
; 26(9): 2328-32, 2016 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26995528
4.
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nat Commun
; 15(1): 482, 2024 Jan 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38228616
5.
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design.
ACS Med Chem Lett
; 14(2): 141-145, 2023 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36793425
6.
Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.
ACS Med Chem Lett
; 13(3): 475-482, 2022 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35300081
7.
Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia.
Sci Transl Med
; 14(659): eabo5228, 2022 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36001679
8.
Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases.
Bioorg Med Chem Lett
; 21(21): 6366-9, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21945284
9.
Evaluating and evolving a screening library in academia: the St Jude approach.
Drug Discov Today
; 26(4): 1060-1069, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33453364
10.
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.
J Med Chem
; 64(11): 7296-7311, 2021 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34042448
11.
Synthesis and Structure-Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases.
J Med Chem
; 63(23): 14885-14904, 2020 12 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33258605
12.
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
J Med Chem
; 63(5): 2013-2027, 2020 03 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31059256
13.
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.
Cancer Res
; 78(6): 1537-1548, 2018 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29343524
14.
Dual Allosteric Inhibition of SHP2 Phosphatase.
ACS Chem Biol
; 13(3): 647-656, 2018 03 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29304282
15.
Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
J Med Chem
; 60(12): 4869-4881, 2017 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28557458
16.
Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.
J Med Chem
; 58(21): 8373-86, 2015 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-26505898
17.
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
Clin Cancer Res
; 20(7): 1834-45, 2014 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24474669
18.
Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
ACS Med Chem Lett
; 4(12): 1193-7, 2013 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900629
19.
7,11-epi-thyrsiferol: completion of its synthesis, evaluation of its antimitotic properties, and the further development of an SAR model.
J Org Chem
; 71(16): 5936-41, 2006 Aug 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-16872175
20.
From C-glycosides to pyranopyrans: an approach to thyrsiferol using titanium(III)-promoted redox couplings.
J Org Chem
; 70(13): 5249-56, 2005 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15960529