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1.
Apilimod dimesylate in C9orf72 amyotrophic lateral sclerosis: a randomized phase 2a clinical trial.
Brain
; 2024 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38606777
2.
Safety, tolerability, pharmacokinetics and pharmacodynamics of parenterally administered dutogliptin: A prospective dose-escalating trial.
Br J Clin Pharmacol
; 86(5): 979-990, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31912513
3.
Metabolic disposition of H3B-8800, an orally available small-molecule splicing modulator, in rats, monkeys, and humans.
Xenobiotica
; 50(9): 1101-1114, 2020 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-31902291
4.
Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of Necuparanib Combined with Nab-Paclitaxel and Gemcitabine in Patients with Metastatic Pancreatic Cancer: Phase I Results.
Oncologist
; 22(12): 1429-e139, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29158367
5.
"Protocol for a phase 2, randomized, double-blind, placebo-controlled, safety and efficacy study of dutogliptin in combination with filgrastim in early recovery post-myocardial infarction": study protocol for a randomized controlled trial.
Trials
; 21(1): 744, 2020 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32843081
6.
Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers.
Cancer Chemother Pharmacol
; 83(1): 91-96, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30368584
7.
M281, an Anti-FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First-in-Human Study.
Clin Pharmacol Ther
; 105(4): 1031-1039, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30402880
8.
A Randomized, First-in-Human, Healthy Volunteer Trial of sutimlimab, a Humanized Antibody for the Specific Inhibition of the Classical Complement Pathway.
Clin Pharmacol Ther
; 104(4): 655-663, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29737533
9.
Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer.
J Clin Oncol
; 22(11): 2108-21, 2004 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15169797
10.
Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain.
J Oral Facial Pain Headache
; 29(3): 286-96, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26244437
11.
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Arthritis Rheum
; 60(7): 2008-18, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19565489
12.
Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes.
Drug Metab Dispos
; 34(4): 702-8, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16443666
13.
Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites.
Drug Metab Dispos
; 33(6): 771-7, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15764713
14.
Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impared renal function.
Cancer
; 103(6): 1195-200, 2005 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15690325
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